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Tdark
TIGD3
Tigger transposable element-derived protein 3

Protein Summary
Description
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309880
  • ENSP00000308354
  • ENSG00000173825
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
tissue sample
0.61
protein domain
0.58
tissue
0.56
transcription factor binding site profile
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
CTPS2
Tbio
Family:  Enzyme
Novelty:  0.06147923
p_int:  0.999973164
p_ni:  0.000026836
Score:  0.933
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.99969992
p_ni:  0.00030008
Data Source:  BioPlex
CTPS1
Tbio
Family:  Enzyme
Novelty:  0.00911596
p_int:  0.997329056
p_ni:  0.002670944
Score:  0.888
Data Source:  BioPlex,STRINGDB
NAT16
Tdark
Family:  Enzyme
Novelty:  0.69697274
p_int:  0.907221077
p_ni:  0.092778912
p_wrong:  1.1e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
RALYL
Tbio
Novelty:  0.20992411
Score:  0.797
Data Source:  STRINGDB
EHBP1L1
Tdark
Novelty:  0.39557718
Score:  0.769
Data Source:  STRINGDB
FRMD8
Tdark
Novelty:  0.39375892
Score:  0.743
Data Source:  STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
Score:  0.712
Data Source:  STRINGDB
CDC42EP2
Tbio
Novelty:  0.21932639
Score:  0.71
Data Source:  STRINGDB
FAM89B
Tbio
Novelty:  0.10306021
Score:  0.702
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
2
3
91.9
glomerular filtration rate
2
2
3
88.3
serum alanine aminotransferase measurement
2
2
1
7.3
73.1
uric acid measurement
1
1
1
69.4
BMI-adjusted hip circumference
2
5
6
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
91.9
glomerular filtration rate
3
88.3
serum alanine aminotransferase measurement
1
7.3
73.1
uric acid measurement
1
69.4
BMI-adjusted hip circumference
6
67.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tigger transposable element derived 3
VGNC:11646
466661
Macaque
tigger transposable element derived 3
719953
Mouse
MGI:2681860
332359
Rat
RGD:1305393
309174
Dog
tigger transposable element derived 3
VGNC:47370
100856184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tigger transposable element derived 3
Macaque
tigger transposable element derived 3
Mouse
Rat
Dog
tigger transposable element derived 3
Publication Statistics
PubMed Score 0.71
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title