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Tbio
TIAM2
T-lymphoma invasion and metastasis-inducing protein 2

Protein Summary
Description
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The enc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275246
  • ENSP00000275246
  • ENSG00000146426
  • ENST00000360366
  • ENSP00000353528
  • ENST00000456877
  • ENSP00000407183
  • ENST00000461783
  • ENSP00000437188
  • ENST00000529824
  • ENSP00000433348

Symbol
  • KIAA2016
  • STEF
  • STEF
  • TIAM-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.81
transcription factor
0.71
cellular component
0.69
tissue sample
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.64   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.64   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.973
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.964
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.964
Data Source:  STRINGDB
RHOF
Tbio
Family:  Enzyme
Novelty:  0.01795771
Score:  0.964
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.954
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.952
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.95
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.949
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.949
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (41)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
5
6
92.3
daytime rest measurement
1
1
1
66.3
appendicular lean mass
1
1
1
53.3
brain measurement
1
1
0
7.6
50.5
basophil count
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
92.3
daytime rest measurement
1
66.3
appendicular lean mass
1
53.3
brain measurement
0
7.6
50.5
basophil count
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1344338
24001
Rat
RGD:2324148
100362710
Dog
T-cell lymphoma invasion and metastasis 2
484045
Horse
T-cell lymphoma invasion and metastasis 2
100061852
Opossum
T-cell lymphoma invasion and metastasis 2
100032275
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
T-cell lymphoma invasion and metastasis 2
Horse
T-cell lymphoma invasion and metastasis 2
Opossum
T-cell lymphoma invasion and metastasis 2
Publication Statistics
PubMed Score 69.64
PubMed score by year
PubTator Score 20.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title