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Tbio
TIAL1
Nucleolysin TIAR

Protein Summary
Description
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369093
  • ENSP00000358089
  • ENSG00000151923
  • ENST00000436547
  • ENSP00000394902

Symbol
  • TCBP
  • TIAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
disease perturbation
0.97
transcription factor binding site profile
0.87
cellular component
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.53   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.53   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (212)
DZIP3
Tbio
Family:  Enzyme
Novelty:  0.12207819
p_int:  1
Score:  0.699
Data Source:  BioPlex,STRINGDB
FAM83H
Tbio
Novelty:  0.02527211
p_int:  0.994651125
p_ni:  0.005348875
Score:  0.198
Data Source:  BioPlex,STRINGDB
TRO
Tbio
Novelty:  0.02850833
p_int:  0.990441005
p_ni:  0.009187961
p_wrong:  0.000371035
Score:  0.195
Data Source:  BioPlex,STRINGDB
SAV1
Tbio
Novelty:  0.00962335
p_int:  0.90744009
p_ni:  0.09255991
Score:  0.207
Data Source:  BioPlex,STRINGDB
INA
Tbio
Novelty:  0.00708581
p_int:  0.76352756
p_ni:  0.163048879
p_wrong:  0.07342356
Score:  0.193
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.973
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.971
Data Source:  STRINGDB
HNRNPF
Tbio
Novelty:  0.01833966
Score:  0.954
Data Source:  STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.4
91.7
electrocardiography
1
1
10
84.6
2
1
0
1.4
82
left ventricular ejection fraction measurement
3
2
3
81.6
heart function measurement
2
1
2
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.4
91.7
electrocardiography
10
84.6
0
1.4
82
left ventricular ejection fraction measurement
3
81.6
heart function measurement
2
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TIA1 cytotoxic granule associated RNA binding protein like 1
VGNC:14329
741374
Macaque
TIA1 cytotoxic granule associated RNA binding protein like 1
703249
Mouse
MGI:107913
21843
Rat
RGD:1595845
361655
Dog
TIA1 cytotoxic granule associated RNA binding protein like 1
VGNC:47364
477841
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TIA1 cytotoxic granule associated RNA binding protein like 1
Macaque
TIA1 cytotoxic granule associated RNA binding protein like 1
Mouse
Rat
Dog
TIA1 cytotoxic granule associated RNA binding protein like 1
Publication Statistics
PubMed Score 87.53
PubMed score by year
PubTator Score 63.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title