THYN1
Thymocyte nuclear protein 1
Protein Summary
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000341541
- ENSP00000341657
- ENSG00000151500
- ENST00000352327
- ENSP00000341452
- ENST00000392594
- ENSP00000376373
- ENST00000392595
- ENSP00000376374
- THY28
- MY105
- THY28
- MDS012
- HSPC144
- THY28KD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
histone modification site profile | 0.91 | ||
virus perturbation | 0.79 | ||
transcription factor binding site profile | 0.68 | ||
cell type or tissue | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.62 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.62 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (35)
GPX7
Family: Enzyme
Novelty: 0.01342855
p_int: 0.999433378
p_ni: 0.00000435
p_wrong: 0.000562272
Score: 0.188
Data Source: BioPlex,STRINGDB
SHPK
Family: Kinase
Novelty: 0.16166855
p_int: 0.958334692
p_ni: 0.041665308
Score: 0.29
Data Source: BioPlex,STRINGDB
ARIH1
Family: Enzyme
Novelty: 0.0258739
p_int: 0.890140614
p_ni: 0.000026072
p_wrong: 0.109833314
Data Source: BioPlex
CALML3
Novelty: 0.0336689
p_int: 0.847045636
p_ni: 0.000011562
p_wrong: 0.152942802
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (1)
Components (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
age at first sexual intercourse measurement | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
age at first sexual intercourse measurement | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thymocyte nuclear protein 1 | VGNC:986 | 451682 | |||||
Mouse | MGI:1925112 | 77862 | ||||||
Rat | RGD:1359525 | 300470 | ||||||
Dog | thymocyte nuclear protein 1 | VGNC:53457 | 489268 | |||||
Horse | thymocyte nuclear protein 1 | VGNC:24098 | 100064816 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thymocyte nuclear protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | thymocyte nuclear protein 1 | |||||
Horse | thymocyte nuclear protein 1 | |||||
Publication Statistics
PubMed Score 9.62
PubMed score by year
PubTator Score 5.87
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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