You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
THYN1
Thymocyte nuclear protein 1

Protein Summary
Description
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341541
  • ENSP00000341657
  • ENSG00000151500
  • ENST00000352327
  • ENSP00000341452
  • ENST00000392594
  • ENSP00000376373
  • ENST00000392595
  • ENSP00000376374

Symbol
  • THY28
  • MY105
  • THY28
  • MDS012
  • HSPC144
  • THY28KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.91
virus perturbation
0.79
transcription factor binding site profile
0.68
cell type or tissue
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.999433378
p_ni:  0.00000435
p_wrong:  0.000562272
Score:  0.188
Data Source:  BioPlex,STRINGDB
SHPK
Tbio
Family:  Kinase
Novelty:  0.16166855
p_int:  0.958334692
p_ni:  0.041665308
Score:  0.29
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.890140614
p_ni:  0.000026072
p_wrong:  0.109833314
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.847045636
p_ni:  0.000011562
p_wrong:  0.152942802
Data Source:  BioPlex
TMA16
Tdark
Novelty:  0.89810617
Score:  0.751
Data Source:  STRINGDB
WDR76
Tbio
Novelty:  0.08744649
Score:  0.749
Data Source:  STRINGDB
TRPT1
Tdark
Family:  Enzyme
Novelty:  0.33062895
Score:  0.74
Data Source:  STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
Score:  0.659
Data Source:  STRINGDB
TMEM201
Tbio
Novelty:  0.00616362
Score:  0.611
Data Source:  STRINGDB
LYAR
Tbio
Novelty:  0.04324088
Score:  0.611
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
15.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thymocyte nuclear protein 1
VGNC:986
451682
Mouse
MGI:1925112
77862
Rat
RGD:1359525
300470
Dog
thymocyte nuclear protein 1
VGNC:53457
489268
Horse
thymocyte nuclear protein 1
VGNC:24098
100064816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thymocyte nuclear protein 1
Mouse
Rat
Dog
thymocyte nuclear protein 1
Horse
thymocyte nuclear protein 1
Publication Statistics
PubMed Score 9.62
PubMed score by year
PubTator Score 5.87
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title