Tbio THYN1 Thymocyte nuclear protein 1

Protein Summary

Description

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9P016
• Q567Q2
• Q9H3L4
• Q9HC20

Gene Name

• THYN1

Ensembl ID

• ENST00000341541
• ENSP00000341657
• ENSG00000151500
• ENST00000352327
• ENSP00000341452
• ENST00000392594
• ENSP00000376373
• ENST00000392595
• ENSP00000376374

Symbol

• THY28
• MY105
• THY28
• MDS012
• HSPC144
• THY28KD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
histone modification site profile	0.91
virus perturbation	0.79
transcription factor binding site profile	0.68
cell type or tissue	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0