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Tbio
THSD7A
Thrombospondin type-1 domain-containing protein 7A

Protein Summary
Description
Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement. Thrombospondin type-1 domain-containing protein 7A, soluble form: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism. The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423059
  • ENSP00000406482
  • ENSG00000005108

Symbol
  • KIAA0960
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
kinase perturbation
0.76
microRNA
0.76
cell type or tissue
0.7
phenotype
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.2   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.2   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.913
Data Source:  STRINGDB
THSD4
Tbio
Novelty:  0.12898073
Score:  0.912
Data Source:  STRINGDB
SPON1
Tbio
Novelty:  0.01071398
Score:  0.911
Data Source:  STRINGDB
THBS2
Tbio
Novelty:  0.00310724
Score:  0.91
Data Source:  STRINGDB
SEMA5B
Tbio
Novelty:  0.0151789
Score:  0.908
Data Source:  STRINGDB
SEMA5A
Tbio
Novelty:  0.00885528
Score:  0.907
Data Source:  STRINGDB
ADAMTS9
Tbio
Family:  Enzyme
Novelty:  0.01447959
Score:  0.904
Data Source:  STRINGDB
THSD7B
Tdark
Novelty:  0.34794254
Score:  0.904
Data Source:  STRINGDB
CFP
Tbio
Novelty:  0.00063251
Score:  0.903
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
4
4
83.1
1
1
0
1.3
77.3
2
1
2
74.6
2
2
0
1.1
65.3
mathematical ability
2
2
3
63.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
83.1
0
1.3
77.3
2
74.6
0
1.1
65.3
mathematical ability
3
63.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thrombospondin type 1 domain containing 7A
VGNC:4537
472294
Mouse
MGI:2685683
330267
Rat
RGD:1566201
500032
Dog
thrombospondin type 1 domain containing 7A
VGNC:47358
100686606
Horse
thrombospondin type 1 domain containing 7A
VGNC:24092
100064843
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thrombospondin type 1 domain containing 7A
Mouse
Rat
Dog
thrombospondin type 1 domain containing 7A
Horse
thrombospondin type 1 domain containing 7A
Publication Statistics
PubMed Score 82.20
PubMed score by year
PubTator Score 30.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title