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Tbio
THSD4
Thrombospondin type-1 domain-containing protein 4

Protein Summary
Description
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261862
  • ENSP00000261862
  • ENSG00000187720
  • ENST00000355327
  • ENSP00000347484
  • ENST00000357769
  • ENSP00000350413

Symbol
  • ADAMTSL6
  • FVSY9334
  • PRO34005
  • ADAMTSL-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
kinase perturbation
0.95
phenotype
0.81
transcription factor perturbation
0.8
disease
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0