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Tbio
THRSP
Thyroid hormone-inducible hepatic protein

Protein Summary
Description
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281030
  • ENSP00000281030
  • ENSG00000151365

Symbol
  • S14
  • Lpgp
  • THRP
  • LPGP1
  • SPOT14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.94
gene perturbation
0.88
cell type or tissue
0.85
disease perturbation
0.79
PubMedID
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.1   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.1   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
ACACB
Tchem
Family:  Enzyme
Novelty:  0.00462116
p_int:  0.999999794
p_ni:  2.06e-7
Score:  0.434
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.99999905
p_ni:  9.5e-7
Score:  0.934
Data Source:  BioPlex,Reactome,STRINGDB
SH3BP1
Tbio
Novelty:  8.50014339
p_int:  0.999995021
p_ni:  0.000004979
Data Source:  BioPlex
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.999985436
p_ni:  0.000014564
Data Source:  BioPlex
TRIM33
Tchem
Family:  Epigenetic
Novelty:  0.00415877
p_int:  0.99991681
p_ni:  0.000083191
Data Source:  BioPlex
PRC1
Tbio
Novelty:  0.0411653
p_int:  0.9996554
p_ni:  0.000011307
p_wrong:  0.000333293
Data Source:  BioPlex
ADNP
Tbio
Family:  TF
Novelty:  0.00785336
p_int:  0.99926677
p_ni:  0.000733229
Data Source:  BioPlex
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999243607
p_ni:  0.000756393
Data Source:  BioPlex
ACACA
Tchem
Family:  Enzyme
Novelty:  0.00248313
p_int:  0.999231516
p_ni:  0.000768484
Score:  0.656
Data Source:  BioPlex,STRINGDB
MBD3
Tbio
Family:  TF
Novelty:  0.04513502
p_int:  0.999216584
p_ni:  0.000783416
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Fatty acid metabolism (R-HSA-8978868)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Import of palmitoyl-CoA into the mitochondrial matrix
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Import of palmitoyl-CoA into the mitochondrial matrix
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone responsive
VGNC:987
466721
Macaque
thyroid hormone responsive
699701
Mouse
MGI:109126
21835
Rat
RGD:3859
25357
Dog
thyroid hormone responsive
VGNC:47356
485169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone responsive
Macaque
thyroid hormone responsive
Mouse
Rat
Dog
thyroid hormone responsive
Publication Statistics
PubMed Score 112.10
PubMed score by year
PubTator Score 79.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title