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Tclin
THRB
Thyroid hormone receptor beta

Protein Summary
Description
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280696
  • ENSP00000280696
  • ENSG00000151090
  • ENST00000356447
  • ENSP00000348827
  • ENST00000396671
  • ENSP00000379904
  • ENST00000415021
  • ENSP00000404898
  • ENST00000416420
  • ENSP00000414444
  • ENST00000642307
  • ENSP00000494618
  • ENST00000643772
  • ENSP00000496029
  • ENST00000644321
  • ENSP00000496616
  • ENST00000645139
  • ENSP00000493709
  • ENST00000646209
  • ENSP00000496686
  • ENST00000646432
  • ENSP00000496509

Symbol
  • ERBA2
  • NR1A2
  • THR1
  • GRTH
  • PRTH
  • THR1
  • ERBA2
  • NR1A2
  • THRB1
  • THRB2
  • C-ERBA-2
  • C-ERBA-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
hub protein
0.85
protein domain
0.85
biological process
0.84
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 740   (req: < 5)
Gene RIFs: 146   (req: <= 3)
Antibodies: 474   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 740   (req: >= 5)
Gene RIFs: 146   (req: > 3)
Antibodies: 474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 242
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3