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Tclin
THRA
Thyroid hormone receptor alpha

Protein Summary
Description
Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264637
  • ENSP00000264637
  • ENSG00000126351
  • ENST00000394121
  • ENSP00000377679
  • ENST00000450525
  • ENSP00000395641
  • ENST00000546243
  • ENSP00000443972
  • ENST00000584985
  • ENSP00000463466

Symbol
  • EAR7
  • ERBA1
  • NR1A1
  • THRA1
  • THRA2
  • AR7
  • EAR7
  • ERBA
  • CHNG6
  • ERBA1
  • NR1A1
  • THRA1
  • THRA2
  • ERB-T-1
  • c-ERBA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.99
hub protein
0.94
protein domain
0.85
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.78   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.78   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 104
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3