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Tbio
THOC3
THO complex subunit 3

Protein Summary
Description
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265097
  • ENSP00000265097
  • ENSG00000051596
  • ENST00000513482
  • ENSP00000422243

Symbol
  • THO3
  • hTREX45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
protein domain
0.73
virus perturbation
0.68
tissue sample
0.65
cellular component
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.33   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.33   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
THOC1
Tbio
Novelty:  0.03702557
p_int:  0.99999842
p_ni:  0.00000158
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC7
Tbio
Novelty:  0.16971494
p_int:  0.999987569
p_ni:  0.000012431
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC5
Tbio
Novelty:  0.04618391
p_int:  0.999918025
p_ni:  0.000081975
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC2
Tbio
Novelty:  0.02886456
p_int:  0.999594136
p_ni:  0.000405864
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.995214168
p_ni:  0.004785832
Data Source:  BioPlex
APPBP2
Tbio
Novelty:  0.14742368
p_int:  0.981778406
p_ni:  0.018215433
p_wrong:  0.000006162
Data Source:  BioPlex
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.981028893
p_ni:  0.018971107
Score:  0.152
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.976495881
p_ni:  0.023504119
Score:  0.161
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.975784118
p_ni:  0.024215882
Score:  0.397
Data Source:  BioPlex,STRINGDB
THOC6
Tbio
Novelty:  0.0744541
p_int:  0.968485449
p_ni:  0.031514551
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THO complex 3
VGNC:4196
462282
Macaque
THO complex 3
695561
Mouse
MGI:1920916
73666
Rat
RGD:1311669
290519
Dog
THO complex 3
VGNC:47350
480781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THO complex 3
Macaque
THO complex 3
Mouse
Rat
Dog
THO complex 3
Publication Statistics
PubMed Score 20.33
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title