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Tdark
THNSL1
Threonine synthase-like 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376356
  • ENSP00000365534
  • ENSG00000185875
  • ENST00000524413
  • ENSP00000434887

Symbol
  • TSH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.77
transcription factor perturbation
0.74
protein domain
0.73
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
FXYD1
Tbio
Family:  IC
Novelty:  0.00421639
p_int:  0.999979452
p_ni:  0.000020548
Score:  0.175
Data Source:  BioPlex,STRINGDB
FOXD4L6
Tdark
Family:  TF
Novelty:  9.78461538
p_int:  0.999961533
p_ni:  0.000038467
Score:  0.186
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.999956075
p_ni:  0.000043925
Data Source:  BioPlex
CCDC74A
Tdark
Novelty:  1.52601156
p_int:  0.999927817
p_ni:  0.000072183
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.999865866
p_ni:  0.000134133
Data Source:  BioPlex
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.999670362
p_ni:  0.000329638
Data Source:  BioPlex
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.99953269
p_ni:  0.000467303
p_wrong:  8e-9
Data Source:  BioPlex
UTP11
Tbio
Novelty:  0.20711838
p_int:  0.999511919
p_ni:  0.000481876
p_wrong:  0.000006205
Score:  0.261
Data Source:  BioPlex,STRINGDB
SPATA24
Tdark
Novelty:  0.95478351
p_int:  0.998741682
p_ni:  0.001258318
Data Source:  BioPlex
TGIF2LY
Tdark
Family:  TF
p_int:  0.998292062
p_ni:  0.001707937
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
9
98.2
neutrophil count
3
3
3
97.2
reticulocyte measurement
3
2
5
96.2
myeloid white cell count
2
2
2
95.6
monocyte count
2
2
2
95.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
98.2
neutrophil count
3
97.2
reticulocyte measurement
5
96.2
myeloid white cell count
2
95.6
monocyte count
2
95.4
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
threonine synthase like 1
VGNC:5819
466271
Macaque
threonine synthase like 1
706766
Mouse
MGI:2139347
208967
Rat
RGD:1564213
498805
Dog
threonine synthase like 1
VGNC:47346
477983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
threonine synthase like 1
Macaque
threonine synthase like 1
Mouse
Rat
Dog
threonine synthase like 1
Publication Statistics
PubMed Score 0.23
PubMed score by year
PubTator Score 49.53
PubTator score by year
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Related Publications
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PMID
Year
Title