Tbio THG1L Probable tRNA(His) guanylyltransferase

Protein Summary

Description

Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9NWX6
• D3DQJ5
• Q53G12
• Q7L5R3
• Q9H0S2

Gene Name

• THG1L

Ensembl ID

• ENST00000231198
• ENSP00000231198
• ENSG00000113272

Symbol

• ICF45
• ICF45
• IHG-1
• hTHG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
histone modification site profile	0.91
kinase perturbation	0.71
disease perturbation	0.68
transcription factor perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 85   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0