Protein Summary
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
- ENST00000368248
- ENSP00000357231
- ENSG00000172673
- ENST00000368250
- ENSP00000357233
- ENST00000537166
- ENSP00000439863
- ENST00000610842
- ENSP00000480630
- ENSG00000275122
- ENST00000613862
- ENSP00000480967
- ENST00000614155
- ENSP00000484170
- ENST00000630369
- ENSP00000487358
- C6orf190
- C6orf207
- GASP
- SPOT
- TSEPA
- C6orf190
- C6orf207
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.65 | ||
tissue sample | 0.58 | ||
microRNA | 0.56 | ||
cellular component | 0.53 | ||
cell line | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.29 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 224 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.29 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 224 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
PTPN11
Family: Enzyme
Novelty: 0.00073124
p_int: 0.9392965
p_ni: 0.06070244
p_wrong: 0.00000106
Score: 0.775
Data Source: BioPlex,STRINGDB
GRB2
Novelty: 0.00091605
p_int: 0.913233132
p_ni: 0.086766868
Score: 0.953
Data Source: BioPlex,STRINGDB
POTEF
Novelty: 0.00191599
p_int: 0.784288881
p_ni: 0.215711119
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
4 | 4 | 1 | 1.2 | 89 | ||||||
4 | 4 | 1 | 1.2 | 89 | ||||||
5 | 5 | 0 | 1.1 | 87 | ||||||
5 | 5 | 0 | 1.1 | 87 | ||||||
childhood onset asthma | 1 | 1 | 0 | 1.1 | 64.4 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.2 | 89 | |||||
1 | 1.2 | 89 | |||||
0 | 1.1 | 87 | |||||
0 | 1.1 | 87 | |||||
childhood onset asthma | 0 | 1.1 | 64.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2443552 | 210757 | ||||||
Dog | thymocyte selection associated | VGNC:47343 | 484120 | |||||
Horse | thymocyte selection associated | VGNC:24077 | 100073059 | |||||
Cow | thymocyte selection associated | VGNC:35835 | 540554 | |||||
Opossum | thymocyte selection associated | 100030867 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | thymocyte selection associated | |||||
Horse | thymocyte selection associated | |||||
Cow | thymocyte selection associated | |||||
Opossum | thymocyte selection associated | |||||
Publication Statistics
PubMed Score 10.29
PubMed score by year
PubTator Score 28.88
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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