Tbio THEM4 Acyl-coenzyme A thioesterase THEM4

Protein Summary

Description

Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5T1C6
• B2RBX2
• Q96KR2
• Acyl-CoA thioesterase THEM4

Gene Name

• THEM4

Ensembl ID

• ENST00000368814
• ENSP00000357804
• ENSG00000159445

Symbol

• CTMP
• CTMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
transcription factor binding site profile	0.82
histone modification site profile	0.78
disease	0.67
pathway	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.62   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.62   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

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1 – 10 of 40

• See Interactions on String-DB

GPT2

Tbio

Family:  Enzyme

Novelty:  0.00478585

p_int:  0.999999993

p_ni:  6e-9

p_wrong:  1e-9

Score:  0.214

Data Source:  BioPlex,STRINGDB

THEM5

Tbio

Family:  Enzyme

Novelty:  0.20267249

p_int:  0.99999994

p_ni:  6e-8

Data Source:  BioPlex

GSTT2

Tdark

Family:  Enzyme

p_int:  0.999999779

p_ni:  1e-9

p_wrong:  2.2e-7

Data Source:  BioPlex

PDSS1

Tbio

Family:  Enzyme

Novelty:  0.01542427

p_int:  0.999986208

p_ni:  0.000013767

p_wrong:  2.5e-8

Score:  0.19

Data Source:  BioPlex,STRINGDB

ALAS1

Tclin

Family:  Enzyme

Novelty:  0.00965779

p_int:  0.99996952

p_ni:  0.00003048

Score:  0.186

Data Source:  BioPlex,STRINGDB

PDSS2

Tbio

Family:  Enzyme

Novelty:  0.02716477

p_int:  0.999963465

p_ni:  0.000002259

p_wrong:  0.000034276

Score:  0.188

Data Source:  BioPlex,STRINGDB

DBT

Tbio

Family:  Enzyme

Novelty:  0.0070589

p_int:  0.999886375

p_ni:  0.000113625

p_wrong:  1e-9

Data Source:  BioPlex

ENOPH1

Tbio

Family:  Enzyme

Novelty:  0.07679925

p_int:  0.999215802

p_ni:  0.000784198

Score:  0.679

Data Source:  BioPlex,STRINGDB

FPGS

Tchem

Family:  Enzyme

Novelty:  0.0108601

p_int:  0.998257037

p_ni:  0.001596583

p_wrong:  0.00014638

Score:  0.189

Data Source:  BioPlex,STRINGDB

SIRT5

Tchem

Family:  Epigenetic

Novelty:  0.00225239

p_int:  0.998135305

p_ni:  0.001838706

p_wrong:  0.000025989

Score:  0.173

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Downstream (2)

1 – 2 of 2

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: PI3K-Akt signaling pathway

RAF1

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: PI3K-Akt signaling pathway

Pathways (306)

Reactome (29)

KEGG (2)

WikiPathways (275)

Activation of AKT2 (R-HSA-165158)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of AKT2	4 targets	R-HSA-165158
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	CD28 co-stimulation	33 targets	R-HSA-389356
Reactome	CD28 dependent PI3K/Akt signaling	22 targets	R-HSA-389357
Reactome	Costimulation by the CD28 family	88 targets	R-HSA-388841

Name	Explore in Pharos	Explore in Source
Activation of AKT2	4 targets	R-HSA-165158
Adaptive Immune System	894 targets	R-HSA-1280218
CD28 co-stimulation	33 targets	R-HSA-389356
CD28 dependent PI3K/Akt signaling	22 targets	R-HSA-389357
Costimulation by the CD28 family	88 targets	R-HSA-388841

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (3)

Components (7)

Processes (5)

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1 – 3 of 3

GO Term	Evidence	Assigned by
palmitoyl-CoA hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB
acyl-CoA hydrolase activity	Traceable Author Statement (TAS)	Reactome
myristoyl-CoA hydrolase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (22)

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5

1 – 5 of 22

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	3	4	4		94.4
serum gamma-glutamyl transferase measurement	EFO_0004532	2	1	2		81.7
asthma	EFO_0000270	2	3	0	1.1	77.1
allergic rhinitis	EFO_0005854	1	1	0	1.1	73.5
Eczema	HP_0000964	1	1	0	1.1	73.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	4		94.4
serum gamma-glutamyl transferase measurement	EFO_0004532	2		81.7
asthma	EFO_0000270	0	1.1	77.1
allergic rhinitis	EFO_0005854	0	1.1	73.5
Eczema	HP_0000964	0	1.1	73.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Apoptosis
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Fatty acid metabolism
Hydrolase
Lipid metabolism

GWAS Trait Find Similar Targets

No Header	No Header
acylcarnitine measurement
allergic rhinitis
allergy
asthma
birth weight
blood metabolite measurement
childhood onset asthma
coronary artery disease
Eczema
eye movement measurement

MGI Phenotype Find Similar Targets

No Header	No Header
liver/biliary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	thioesterase superfamily member 4	VGNC:10934	457305
Macaque	thioesterase superfamily member 4		711796
Mouse	thioesterase superfamily member 4	MGI:1923028	75778
Rat	thioesterase superfamily member 4	RGD:1304723	361992
Dog	thioesterase superfamily member 4	VGNC:47341	609163

Species	Name	OMA	EggNOG	Inparanoid
Chimp	thioesterase superfamily member 4
Macaque	thioesterase superfamily member 4
Mouse	thioesterase superfamily member 4
Rat	thioesterase superfamily member 4
Dog	thioesterase superfamily member 4

Publication Statistics

PubMed Score 60.62

PubMed score by year

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PubTator Score 38.52

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (8)

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PMID	Year	Title