THEM4
Acyl-coenzyme A thioesterase THEM4
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.82 | ||
histone modification site profile | 0.78 | ||
disease | 0.67 | ||
pathway | 0.65 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of AKT2 | ||||
Reactome | Adaptive Immune System | ||||
Reactome | CD28 co-stimulation | ||||
Reactome | CD28 dependent PI3K/Akt signaling | ||||
Reactome | Costimulation by the CD28 family | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of AKT2 | ||||
Adaptive Immune System | ||||
CD28 co-stimulation | ||||
CD28 dependent PI3K/Akt signaling | ||||
Costimulation by the CD28 family | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
blood metabolite measurement | 3 | 4 | 4 | 94.4 | |||||
serum gamma-glutamyl transferase measurement | 2 | 1 | 2 | 81.7 | |||||
2 | 3 | 0 | 1.1 | 77.1 | |||||
1 | 1 | 0 | 1.1 | 73.5 | |||||
Eczema | 1 | 1 | 0 | 1.1 | 73.5 | ||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
blood metabolite measurement | 4 | 94.4 | |||||
serum gamma-glutamyl transferase measurement | 2 | 81.7 | |||||
0 | 1.1 | 77.1 | |||||
0 | 1.1 | 73.5 | |||||
Eczema | 0 | 1.1 | 73.5 | ||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | thioesterase superfamily member 4 | VGNC:10934 | 457305 | |||||
Macaque | thioesterase superfamily member 4 | 711796 | ||||||
Mouse | MGI:1923028 | 75778 | ||||||
Rat | RGD:1304723 | 361992 | ||||||
Dog | thioesterase superfamily member 4 | VGNC:47341 | 609163 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | thioesterase superfamily member 4 | |||||
Macaque | thioesterase superfamily member 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | thioesterase superfamily member 4 | |||||
PMID | Year | Title |
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