You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
THBS3
Thrombospondin-3

Protein Summary
Description
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368378
  • ENSP00000357362
  • ENSG00000169231
  • ENST00000457183
  • ENSP00000392207

Symbol
  • TSP3
  • TSP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
histone modification site profile
0.75
transcription factor binding site profile
0.68
transcription factor
0.66
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
THBS1
Tchem
Novelty:  0.00073905
p_int:  0.999998576
p_ni:  4.9e-8
p_wrong:  0.000001376
Score:  0.238
Data Source:  BioPlex,STRINGDB
THBS4
Tbio
Novelty:  0.00988079
p_int:  0.999975769
p_wrong:  0.000024231
Score:  0.24
Data Source:  BioPlex,STRINGDB
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.999929427
p_ni:  0.000070573
Data Source:  BioPlex
FANCB
Tbio
Novelty:  0.00268111
p_int:  0.999869827
p_ni:  0.000112551
p_wrong:  0.000017622
Score:  0.186
Data Source:  BioPlex,STRINGDB
PDE7A
Tclin
Family:  Enzyme
Novelty:  0.00872596
p_int:  0.999783802
p_ni:  0.000216191
p_wrong:  7e-9
Score:  0.184
Data Source:  BioPlex,STRINGDB
CORO7
Tbio
Novelty:  0.14307384
p_int:  0.999783802
p_ni:  0.000216191
p_wrong:  7e-9
Data Source:  BioPlex
IQSEC2
Tbio
Novelty:  0.01878611
p_int:  0.999354666
p_ni:  0.000192214
p_wrong:  0.00045312
Score:  0.208
Data Source:  BioPlex,STRINGDB
C5orf34
Tdark
Novelty:  1.01063928
p_int:  0.997516702
p_ni:  0.002480588
p_wrong:  0.00000271
Score:  0.183
Data Source:  BioPlex,STRINGDB
SH3BP4
Tbio
Novelty:  0.13130398
p_int:  0.996557598
p_ni:  0.003163873
p_wrong:  0.000278529
Data Source:  BioPlex
BLVRA
Tbio
Family:  Enzyme
Novelty:  0.00526407
p_int:  0.996393393
p_ni:  0.003606607
Score:  0.229
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by PDGF
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by PDGF
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
5
9
98.3
serum gamma-glutamyl transferase measurement
3
4
3
3.7
98
serum urea measurement
2
3
3
95.4
reticulocyte measurement
3
2
4
93.8
cancer antigen 15.3 measurement
1
2
2
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
98.3
serum gamma-glutamyl transferase measurement
3
3.7
98
serum urea measurement
3
95.4
reticulocyte measurement
4
93.8
cancer antigen 15.3 measurement
2
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thrombospondin 3
VGNC:1671
457359
Macaque
thrombospondin 3
717572
Mouse
MGI:98739
21827
Dog
thrombospondin 3
VGNC:47337
610359
Horse
thrombospondin 3
VGNC:24074
100063449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thrombospondin 3
Macaque
thrombospondin 3
Mouse
Dog
thrombospondin 3
Horse
thrombospondin 3
Publication Statistics
PubMed Score 54.04
PubMed score by year
PubTator Score 23.83
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title