Tbio THBS3 Thrombospondin-3

Protein Summary

Description

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P49746
• B1AVR8
• B4DQ20
• Q8WV34

Gene Name

• THBS3

Ensembl ID

• ENST00000368378
• ENSP00000357362
• ENSG00000169231
• ENST00000457183
• ENSP00000392207

Symbol

• TSP3
• TSP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
histone modification site profile	0.75
transcription factor binding site profile	0.68
transcription factor	0.66
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.7   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.7   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0