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Tbio
THBS2
Thrombospondin-2

Protein Summary
Description
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366787
  • ENSP00000355751
  • ENSG00000186340
  • ENST00000617924
  • ENSP00000482784

Symbol
  • TSP2
  • TSP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.92
small molecule perturbation
0.67
gene perturbation
0.64
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.22   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.22   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (171)
THBS1
Tchem
Novelty:  0.00073905
p_int:  1
Score:  0.942
Data Source:  BioPlex,STRINGDB
DPY19L3
Tbio
Family:  Enzyme
Novelty:  0.35244121
p_int:  0.999994868
p_ni:  0.000004949
p_wrong:  1.83e-7
Score:  0.194
Data Source:  BioPlex,STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
p_int:  0.999964356
p_ni:  0.000035643
p_wrong:  1e-9
Score:  0.948
Data Source:  BioPlex,STRINGDB
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.999513265
p_ni:  0.000486735
Data Source:  BioPlex
PPP1R21
Tdark
Family:  Enzyme
Novelty:  0.33099657
p_int:  0.997022826
p_ni:  0.00297715
p_wrong:  2.4e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
p_int:  0.986956731
p_ni:  0.013043269
Data Source:  BioPlex
AP1G2
Tbio
Novelty:  0.17203425
p_int:  0.985939374
p_ni:  0.014060626
Score:  0.173
Data Source:  BioPlex,STRINGDB
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.960075958
p_ni:  0.039924042
Data Source:  BioPlex
FOXF2
Tbio
Family:  TF
Novelty:  0.02032168
p_int:  0.927673764
p_ni:  0.010344012
p_wrong:  0.061982224
Score:  0.218
Data Source:  BioPlex,STRINGDB
ZNF696
Tdark
Family:  TF
Novelty:  3.49300122
p_int:  0.8717427
p_ni:  0.128250233
p_wrong:  0.000007067
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
1.5
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
1.5
10.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98738
21826
Rat
RGD:1310979
292406
Dog
thrombospondin 2
VGNC:47336
484087
Horse
thrombospondin 2
VGNC:24073
100050044
Cow
thrombospondin 2
VGNC:35829
338092
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
thrombospondin 2
Horse
thrombospondin 2
Cow
thrombospondin 2
Publication Statistics
PubMed Score 374.22
PubMed score by year
PubTator Score 185.96
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title