Protein Summary
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
- ENST00000260356
- ENSP00000260356
- ENSG00000137801
- TSP
- TSP1
- TSP
- THBS
- TSP1
- TSP-1
- THBS-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
protein domain | 1 | ||
PubMedID | 1 | ||
molecular function | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1555.12 (req: < 5)
Gene RIFs: 348 (req: <= 3)
Antibodies: 655 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1555.12 (req: >= 5)
Gene RIFs: 348 (req: > 3)
Antibodies: 655 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 83
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (14)
Protein-Protein Interactions (357)
THBS3
Novelty: 0.01915634
p_int: 0.999998576
p_ni: 4.9e-8
p_wrong: 0.000001376
Score: 0.238
Data Source: BioPlex,STRINGDB
FCGRT
Novelty: 0.00105713
p_int: 0.9999972
p_ni: 0.0000028
Score: 0.191
Data Source: BioPlex,STRINGDB
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999969539
p_ni: 0.000030447
p_wrong: 1.3e-8
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
Pathways (135)
Reactome (24)
KEGG (12)
PathwayCommons (4)
WikiPathways (95)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (97)
Functions (14)
Components (14)
Processes (69)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cortical surface area measurement | 1 | 2 | 0 | 21.2 | 56.8 | ||||
urate measurement | 1 | 1 | 1 | 39.6 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 14.2 | |||||
serum alanine aminotransferase measurement | 1 | 1 | 1 | 6.7 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cortical surface area measurement | 0 | 21.2 | 56.8 | ||||
urate measurement | 1 | 39.6 | |||||
serum gamma-glutamyl transferase measurement | 1 | 14.2 | |||||
serum alanine aminotransferase measurement | 1 | 6.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thrombospondin 1 | VGNC:1597 | 453319 | |||||
Macaque | thrombospondin 1 | 705413 | ||||||
Mouse | MGI:98737 | 21825 | ||||||
Dog | thrombospondin 1 | VGNC:47335 | 487486 | |||||
Horse | thrombospondin 1 | VGNC:24072 | 100057478 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thrombospondin 1 | |||||
Macaque | thrombospondin 1 | |||||
Mouse | ||||||
Dog | thrombospondin 1 | |||||
Horse | thrombospondin 1 | |||||
Publication Statistics
PubMed Score 1555.12
PubMed score by year
PubTator Score 2123.39
PubTator score by year
Related Publications
Text Mined References (452)
GeneRif Annotations (348)
Items per page:
0 of 0
PMID | Year | Title |
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