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Tbio
THAP4
THAP domain-containing protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402136
  • ENSP00000385931
  • ENSG00000176946
  • ENST00000407315
  • ENSP00000385006

Symbol
  • PP238
  • CGI-36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.81
cellular component
0.75
disease perturbation
0.74
histone modification site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.992771757
p_ni:  0.007228243
Score:  0.549
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.99056029
p_ni:  0.00943971
Data Source:  BioPlex
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.849002641
p_ni:  0.150997359
Score:  0.553
Data Source:  BioPlex,STRINGDB
GFER
Tchem
Family:  Enzyme
Novelty:  0.00338563
p_int:  0.840729498
p_ni:  0.159096591
p_wrong:  0.000173912
Score:  0.676
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.831840284
p_ni:  0.168159716
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.830098375
p_ni:  0.169901625
Data Source:  BioPlex
THAP11
Tbio
Family:  TF
Novelty:  0.0679686
Score:  0.921
Data Source:  STRINGDB
THAP12
Tbio
Family:  TF
Novelty:  0.21092098
Score:  0.8
Data Source:  STRINGDB
HSPA4L
Tbio
Novelty:  0.05591399
Score:  0.719
Data Source:  STRINGDB
ANKMY1
Tbio
Novelty:  0.15068511
Score:  0.709
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
72.5
hematocrit
2
2
2
68.1
vital capacity
1
1
1
65.5
hemoglobin measurement
2
2
2
59.4
body height
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
72.5
hematocrit
2
68.1
vital capacity
1
65.5
hemoglobin measurement
2
59.4
body height
1
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
THAP domain containing 4
701543
Mouse
MGI:1914276
67026
Rat
RGD:1359473
363291
Dog
THAP domain containing 4
486208
Cow
THAP domain containing 4
507503
Species
Name
OMA
EggNOG
Inparanoid
Macaque
THAP domain containing 4
Mouse
Rat
Dog
THAP domain containing 4
Cow
THAP domain containing 4
Publication Statistics
PubMed Score 5.26
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title