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Tdark
THAP2
THAP domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308086
  • ENSP00000310796
  • ENSG00000173451
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.88
transcription factor binding site profile
0.81
microRNA
0.62
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
CTNNBL1
Tbio
Novelty:  0.0189038
p_int:  0.999395263
p_ni:  0.000604734
p_wrong:  2e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
TRIM71
Tbio
Family:  Enzyme
Novelty:  0.01164618
p_int:  0.998203274
p_ni:  0.001796726
Score:  0.252
Data Source:  BioPlex,STRINGDB
DNAJB8
Tbio
Novelty:  0.0791748
p_int:  0.961821881
p_ni:  0.000849946
p_wrong:  0.037328173
Score:  0.234
Data Source:  BioPlex,STRINGDB
HCFC2
Tbio
Novelty:  0.12260416
p_int:  0.908942917
p_ni:  0.091057083
Score:  0.793
Data Source:  BioPlex,STRINGDB
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
p_int:  0.873818487
p_ni:  0.126181513
Score:  0.672
Data Source:  BioPlex,STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
p_int:  0.813426944
p_ni:  0.186573056
Score:  0.783
Data Source:  BioPlex,STRINGDB
THAP11
Tbio
Family:  TF
Novelty:  0.0679686
Score:  0.8
Data Source:  STRINGDB
TMEM19
Tdark
Novelty:  1.22010943
Score:  0.605
Data Source:  STRINGDB
BAZ2A
Tchem
Family:  TF; Epigenetic
Novelty:  0.00478642
Score:  0.58
Data Source:  STRINGDB
FAM49A
Tdark
Novelty:  0.40489408
Score:  0.573
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
55.2
Cleft palate
1
1
0
1.2
55.2
electrocardiography
1
1
2
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
55.2
Cleft palate
0
1.2
55.2
electrocardiography
2
5.3
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 2
VGNC:13467
100610645
Mouse
MGI:1914066
66816
Rat
RGD:1593643
688019
Dog
THAP domain containing 2
VGNC:47327
100683172
Horse
THAP domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20854]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 2
Mouse
Rat
Dog
THAP domain containing 2
Horse
THAP domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20854]
Publication Statistics
PubMed Score 4.09
PubMed score by year
PubTator Score 3.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title