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Tbio
THAP12
52 kDa repressor of the inhibitor of the protein kinase

Protein Summary
Description
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260045
  • ENSP00000260045
  • ENSG00000137492

Symbol
  • DAP4
  • P52RIPK
  • PRKRIR
  • THAP0
  • DAP4
  • THAP0
  • PRKRIR
  • P52rIPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.47   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.47   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ZNF526
Tdark
Family:  TF
Novelty:  0.66743234
p_int:  0.999998316
p_ni:  1.17e-7
p_wrong:  0.000001567
Data Source:  BioPlex
ZNF574
Tdark
Family:  TF
Novelty:  2.72596185
p_int:  0.99999163
p_ni:  0.000008371
Score:  0.708
Data Source:  BioPlex,STRINGDB
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.999462572
p_ni:  0.000537428
Data Source:  BioPlex
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
p_int:  0.999356819
p_ni:  0.000643181
Score:  0.518
Data Source:  BioPlex,STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.995212357
p_ni:  0.004787643
Data Source:  BioPlex
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.980572862
p_ni:  0.019427138
Data Source:  BioPlex
ASB10
Tbio
Novelty:  0.08667666
p_int:  0.95311405
p_ni:  0.04688595
Score:  0.309
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.925756026
p_ni:  0.074243974
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.924565827
p_ni:  0.075384297
p_wrong:  0.000049877
Data Source:  BioPlex
LRRC73
Tdark
Novelty:  48
p_int:  0.894768326
p_ni:  0.105230174
p_wrong:  0.0000015
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
38.1
self reported educational attainment
1
1
1
15.8
sex hormone-binding globulin measurement
2
1
2
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
38.1
self reported educational attainment
1
15.8
sex hormone-binding globulin measurement
2
10.6
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 12
VGNC:7654
748747
Mouse
MGI:1920231
72981
Dog
THAP domain containing 12
VGNC:47326
485182
Horse
THAP domain containing 12
VGNC:24068
100064157
Cow
THAP domain containing 12
VGNC:35820
508969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 12
Mouse
Dog
THAP domain containing 12
Horse
THAP domain containing 12
Cow
THAP domain containing 12
Publication Statistics
PubMed Score 3.47
PubMed score by year
PubTator Score 3.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title