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Tbio
THAP11
THAP domain-containing protein 11

Protein Summary
Description
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303596
  • ENSP00000304689
  • ENSG00000168286

Symbol
  • RONIN
  • CTG-B43a
  • CTG-B45d
  • HRIHFB2206
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.76
transcription factor binding site profile
0.76
virus perturbation
0.64
transcription factor
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.16   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.16   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
p_int:  0.999903714
p_ni:  0.000096164
p_wrong:  1.22e-7
Data Source:  BioPlex
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.999879597
p_ni:  0.000120403
Score:  0.203
Data Source:  BioPlex,STRINGDB
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999530604
p_ni:  0.000469395
p_wrong:  2e-9
Data Source:  BioPlex
LHFPL2
Tdark
Novelty:  0.85421144
p_int:  0.997681151
p_ni:  0.002318762
p_wrong:  8.7e-8
Data Source:  BioPlex
ABRAXAS2
Tbio
Novelty:  0.20430604
p_int:  0.997209271
p_ni:  0.002790655
p_wrong:  7.4e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.994917738
p_ni:  0.004662639
p_wrong:  0.000419623
Data Source:  BioPlex
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.993249668
p_ni:  0.006743993
p_wrong:  0.000006339
Data Source:  BioPlex
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.992930506
p_ni:  0.007054594
p_wrong:  0.000014901
Score:  0.811
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.990006353
p_ni:  0.009511482
p_wrong:  0.000482164
Data Source:  BioPlex
HCFC1
Tbio
Novelty:  0.00440762
p_int:  0.98662303
p_ni:  0.01337697
Score:  0.87
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
37
15
47
10
99.7
apolipoprotein A 1 measurement
3
5
6
90.4
total cholesterol measurement
5
3
6
87.7
hemoglobin measurement
4
3
4
84.1
stem Cell Factor measurement
1
2
2
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
47
10
99.7
apolipoprotein A 1 measurement
6
90.4
total cholesterol measurement
6
87.7
hemoglobin measurement
4
84.1
stem Cell Factor measurement
2
83.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
THAP domain containing 11
700354
Mouse
MGI:1930964
59016
Rat
RGD:1310268
307806
Dog
THAP domain containing 11
VGNC:47325
489752
Horse
THAP domain containing 11 [Source:HGNC Symbol;Acc:HGNC:23194]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
THAP domain containing 11
Mouse
Rat
Dog
THAP domain containing 11
Horse
THAP domain containing 11 [Source:HGNC Symbol;Acc:HGNC:23194]
Publication Statistics
PubMed Score 29.16
PubMed score by year
PubTator Score 17.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title