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Tdark
THAP10
THAP domain-containing protein 10

Protein Summary
Description
This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249861
  • ENSP00000249861
  • ENSG00000129028
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
tissue sample
0.61
virus perturbation
0.59
cellular component
0.48
transcription factor perturbation
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
p_int:  0.881744351
p_ni:  0.118255649
Score:  0.685
Data Source:  BioPlex,STRINGDB
LRRC49
Tdark
Novelty:  0.19477281
Score:  0.741
Data Source:  STRINGDB
DAW1
Tdark
Novelty:  0.08712536
Score:  0.693
Data Source:  STRINGDB
THAP8
Tdark
Family:  TF
Novelty:  3.10152067
Score:  0.669
Data Source:  STRINGDB
THAP4
Tbio
Family:  TF
Novelty:  0.19820029
Score:  0.569
Data Source:  STRINGDB
THAP6
Tdark
Family:  TF
Novelty:  3.35556738
Score:  0.559
Data Source:  STRINGDB
THAP9
Tbio
Family:  TF
Novelty:  0.25915023
Score:  0.543
Data Source:  STRINGDB
THAP7
Tbio
Family:  TF
Novelty:  0.37300241
Score:  0.53
Data Source:  STRINGDB
DNAL4
Tbio
Novelty:  0.15546154
Score:  0.529
Data Source:  STRINGDB
THAP5
Tdark
Family:  TF
Novelty:  0.35634978
Score:  0.525
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 10
VGNC:1598
467812
Macaque
THAP domain containing 10
696770
Dog
THAP domain containing 10
611157
Cow
THAP domain containing 10
785266
Opossum
THAP domain containing 10
100026983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THAP domain containing 10
Macaque
THAP domain containing 10
Dog
THAP domain containing 10
Cow
THAP domain containing 10
Opossum
THAP domain containing 10
Publication Statistics
PubMed Score 1.46
PubMed score by year
PubTator Score 0.70
PubTator score by year
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Related Publications
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PMID
Year
Title