TH
Tyrosine 3-monooxygenase
Protein Summary
Plays an important role in the physiology of adrenergic neurons. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
- ENST00000333684
- ENSP00000328814
- ENSG00000180176
- ENST00000352909
- ENSP00000325951
- ENST00000381175
- ENSP00000370567
- ENST00000381178
- ENSP00000370571
- TYH
- TYH
- DYT14
- DYT5b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
kinase | 0.99 | ||
molecular function | 0.95 | ||
biological term | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2728.85 (req: < 5)
Gene RIFs: 162 (req: <= 3)
Antibodies: 1508 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2728.85 (req: >= 5)
Gene RIFs: 162 (req: > 3)
Antibodies: 1508 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 67
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1