Protein Summary
Plays an important role in the physiology of adrenergic neurons. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
- ENST00000333684
- ENSP00000328814
- ENSG00000180176
- ENST00000352909
- ENSP00000325951
- ENST00000381175
- ENSP00000370567
- ENST00000381178
- ENSP00000370571
- TYH
- TYH
- DYT14
- DYT5b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
kinase | 0.99 | ||
molecular function | 0.95 | ||
biological term | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2464.45 (req: < 5)
Gene RIFs: 143 (req: <= 3)
Antibodies: 1508 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2464.45 (req: >= 5)
Gene RIFs: 143 (req: > 3)
Antibodies: 1508 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 67
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (3)
Protein-Protein Interactions (275)
KDM3B
Family: Epigenetic
Novelty: 0.05322289
p_int: 0.99999982
p_ni: 1.79e-7
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
NFIC
Family: TF
Novelty: 0.00438636
p_int: 0.999999396
p_ni: 3.71e-7
p_wrong: 2.32e-7
Score: 0.281
Data Source: BioPlex,STRINGDB
RELL1
Novelty: 0.28949625
p_int: 0.999990475
p_ni: 0.000009336
p_wrong: 1.89e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
DNAJC12
Novelty: 0.05214775
p_int: 0.999989971
p_ni: 0.000010029
Score: 0.186
Data Source: BioPlex,STRINGDB
ZBTB34
Family: TF
Novelty: 0.5693361
p_int: 0.999969092
p_ni: 8.32e-7
p_wrong: 0.000030075
Score: 0.199
Data Source: BioPlex,STRINGDB
MTFR2
Novelty: 0.20272025
p_int: 0.999933769
p_ni: 0.00006621
p_wrong: 2.1e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
MAP3K7
Family: Kinase
Novelty: 0.00540177
p_int: 0.999518484
p_ni: 0.000481515
Score: 0.169
Data Source: BioPlex,STRINGDB
TAOK2
Family: Kinase
Novelty: 0.0232708
p_int: 0.994501834
p_ni: 0.005444694
p_wrong: 0.000053472
Score: 0.188
Data Source: BioPlex,STRINGDB
TAB1
Family: Kinase
Novelty: 0.00721424
p_int: 0.909738913
p_ni: 0.090261085
p_wrong: 2e-9
Score: 0.172
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (34)
Reactome (4)
KEGG (9)
PathwayCommons (9)
UniProt (1)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Catecholamine biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amine-derived hormones | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Catecholamine biosynthesis | ||||
Metabolism | ||||
Metabolism of amine-derived hormones | ||||
Metabolism of amino acids and derivatives | ||||
Viral Interactions (0)
Gene Ontology Terms (81)
Functions (9)
Components (14)
Processes (58)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (29)
Items per page:
1 – 5 of 29
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
IGF-1 measurement | 1 | 8 | 8 | 99.2 | |||||
12 | 12 | 2 | 1.2 | 99.1 | |||||
6 | 6 | 2 | 1.6 | 99.1 | |||||
6 | 4 | 0 | 1.2 | 94.1 | |||||
glomerular filtration rate | 5 | 6 | 6 | 7 | 91.9 | ||||
Items per page:
1 – 5 of 29
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
IGF-1 measurement | 8 | 99.2 | |||||
2 | 1.2 | 99.1 | |||||
2 | 1.6 | 99.1 | |||||
0 | 1.2 | 94.1 | |||||
glomerular filtration rate | 6 | 7 | 91.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tyrosine hydroxylase | VGNC:988 | 450955 | |||||
Macaque | tyrosine hydroxylase | 721137 | ||||||
Mouse | MGI:98735 | 21823 | ||||||
Rat | RGD:3853 | 25085 | ||||||
Dog | tyrosine hydroxylase | VGNC:47322 | 403444 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tyrosine hydroxylase | |||||
Macaque | tyrosine hydroxylase | |||||
Mouse | ||||||
Rat | ||||||
Dog | tyrosine hydroxylase | |||||
Publication Statistics
PubMed Score 2464.45
PubMed score by year
PubTator Score 1083.25
PubTator score by year
Related Publications
Text Mined References (218)
GeneRif Annotations (143)
Items per page:
0 of 0
PMID | Year | Title |
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