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Tbio
TGOLN2
Trans-Golgi network integral membrane protein 2

Protein Summary
Description
May be involved in regulating membrane traffic to and from trans-Golgi network. This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282120
  • ENSP00000282120
  • ENSG00000152291
  • ENST00000377386
  • ENSP00000366603
  • ENST00000398263
  • ENSP00000381312
  • ENST00000409232
  • ENSP00000386443
  • ENST00000444342
  • ENSP00000391190

Symbol
  • TGN46
  • TGN51
  • TGN38
  • TGN46
  • TGN48
  • TGN51
  • TTGN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
disease perturbation
0.96
transcription factor perturbation
0.84
microRNA
0.77


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.36   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.36   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0