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Tbio
TGM4
Protein-glutamine gamma-glutamyltransferase 4

Protein Summary
Description
Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296125
  • ENSP00000296125
  • ENSG00000163810
  • ENST00000628744
  • ENSP00000487307
  • ENSG00000281886

Symbol
  • TGP
  • hTGP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.63
cell type or tissue
0.54
gene perturbation
0.5
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.66   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.66   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
GAB2
Tbio
Novelty:  0.00697372
p_int:  0.999999992
p_ni:  7e-9
p_wrong:  1e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.999988346
p_ni:  0.000011386
p_wrong:  2.69e-7
Score:  0.297
Data Source:  BioPlex,STRINGDB
ACPP
Tchem
Family:  Enzyme
Novelty:  0.00364265
Score:  0.755
Data Source:  STRINGDB
KLK2
Tchem
Family:  Enzyme
Novelty:  0.00511717
Score:  0.719
Data Source:  STRINGDB
KLKB1
Tclin
Family:  Enzyme
Novelty:  0.00109438
Score:  0.714
Data Source:  STRINGDB
MSMB
Tbio
Novelty:  0.00241546
Score:  0.65
Data Source:  STRINGDB
F13B
Tbio
Novelty:  0.00562478
Score:  0.646
Data Source:  STRINGDB
STEAP4
Tbio
Family:  Enzyme
Novelty:  0.01926607
Score:  0.643
Data Source:  STRINGDB
STEAP2
Tbio
Family:  Enzyme
Novelty:  0.02727622
Score:  0.642
Data Source:  STRINGDB
KLK14
Tchem
Family:  Enzyme
Novelty:  0.02007434
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
60.5
1
1
0
1.5
60.5
pulse pressure measurement
1
1
1
50.6
pulse pressure measurement
1
1
1
50.6
macrophage inflammatory protein 1b measurement
1
2
2
49.2
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
60.5
0
1.5
60.5
pulse pressure measurement
1
50.6
pulse pressure measurement
1
50.6
macrophage inflammatory protein 1b measurement
2
49.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 4
VGNC:12204
460311
Mouse
MGI:3027002
331046
Rat
RGD:620785
64679
Anole lizard
protein-glutamine gamma-glutamyltransferase 4
100568257
Xenopus
transglutaminase 4
XB-GENE-1012962
100488625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 4
Mouse
Rat
Anole lizard
protein-glutamine gamma-glutamyltransferase 4
Xenopus
transglutaminase 4
Publication Statistics
PubMed Score 72.66
PubMed score by year
PubTator Score 40.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title