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Tchem
TGM3
Protein-glutamine gamma-glutamyltransferase E

Protein Summary
Description
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381458
  • ENSP00000370867
  • ENSG00000125780

Symbol
  • TGE
  • UHS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.71
gene perturbation
0.7
PubMedID
0.68
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (53)
PPME1
Tchem
Family:  Enzyme
Novelty:  0.01559862
p_int:  0.999497841
p_ni:  0.000502156
p_wrong:  3e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.9384716
p_ni:  0.0615284
Data Source:  BioPlex
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.895465827
p_ni:  0.104534173
Score:  0.158
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.881033813
p_ni:  0.118966187
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.837586255
p_ni:  0.162413745
Data Source:  BioPlex
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.784905313
p_ni:  0.215094687
Data Source:  BioPlex
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.78053801
p_ni:  0.21946199
Data Source:  BioPlex
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.778204934
p_ni:  0.221795066
Data Source:  BioPlex
CALML5
Tbio
Novelty:  0.03240679
Score:  0.84
Data Source:  STRINGDB
GSTO1
Tchem
Family:  Enzyme
Novelty:  0.00800915
Score:  0.839
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
6
3
1.2
98.5
keratinocyte carcinoma
1
3
0
1.1
94
1
1
0
1.3
49.5
non-melanoma skin carcinoma
1
1
0
1.3
21.1
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.2
98.5
keratinocyte carcinoma
0
1.1
94
0
1.3
49.5
non-melanoma skin carcinoma
0
1.3
21.1
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 3
VGNC:6281
458043
Macaque
transglutaminase 3
716498
Mouse
MGI:98732
21818
Rat
RGD:1561831
366189
Dog
transglutaminase 3
VGNC:47317
477180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 3
Macaque
transglutaminase 3
Mouse
Rat
Dog
transglutaminase 3
Publication Statistics
PubMed Score 83.00
PubMed score by year
PubTator Score 74.84
PubTator score by year
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Related Publications
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PMID
Year
Title