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Tchem
TGM2
Protein-glutamine gamma-glutamyltransferase 2

Protein Summary
Description
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361475
  • ENSP00000355330
  • ENSG00000198959

Symbol
  • TGC
  • TG(C)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
gene perturbation
0.98
PubMedID
0.94
small molecule perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2541.32   (req: < 5)
Gene RIFs: 347   (req: <= 3)
Antibodies: 1101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2541.32   (req: >= 5)
Gene RIFs: 347   (req: > 3)
Antibodies: 1101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 196
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0