Tchem TGFBR2 TGF-beta receptor type-2

Protein Summary

Description

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P37173
• B4DTV5
• Q15580
• Q6DKT6
• Q99474
• TGFR-2

Gene Name

• TGFBR2

Ensembl ID

• ENST00000295754
• ENSP00000295754
• ENSG00000163513
• ENST00000359013
• ENSP00000351905

Symbol

• AAT3
• FAA3
• LDS2
• MFS2
• RIIC
• LDS1B
• LDS2B
• TAAD2
• TBRII
• TBR-ii
• TGFR-2
• TGFbeta-RII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
hub protein	0.99
PubMedID	0.98
transcription factor perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Tgf-beta Receptor Type-2

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Tgf-beta Receptor Type-2

Protein / Receptor / Cytokine Receptor / Tgf-beta Receptor / Tgf-beta Receptor Type-2

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Stkr Family / Stkr Type 2 Subfamily / Tgf-beta Receptor Type-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1284.22   (req: < 5)

Gene RIFs: 426   (req: <= 3)

Antibodies: 734   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1284.22   (req: >= 5)

Gene RIFs: 426   (req: > 3)

Antibodies: 734   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0