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Tbio
TGFBI
Transforming growth factor-beta-induced protein ig-h3

Protein Summary
Description
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442011
  • ENSP00000416330
  • ENSG00000120708

Symbol
  • BIGH3
  • CSD
  • CDB1
  • CDG2
  • CSD1
  • CSD2
  • CSD3
  • EBMD
  • LCD1
  • BIGH3
  • CDGG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
virus perturbation
0.97
gene perturbation
0.96
biological term
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.81   (req: < 5)
Gene RIFs: 240   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.81   (req: >= 5)
Gene RIFs: 240   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0