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Tbio
TGFB3
Transforming growth factor beta-3 proprotein

Protein Summary
Description
Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238682
  • ENSP00000238682
  • ENSG00000119699
  • ENST00000556285
  • ENSP00000451110

Symbol
  • ARVD
  • LDS5
  • RNHF
  • ARVD1
  • TGF-beta3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.92
disease perturbation
0.9
biological term
0.88
gene perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.24   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 434   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.24   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 434   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0