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Tbio
TGFB2
Transforming growth factor beta-2 proprotein

Protein Summary
Description
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity). Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366929
  • ENSP00000355896
  • ENSG00000092969
  • ENST00000366930
  • ENSP00000355897

Symbol
  • LDS4
  • G-TSF
  • TGF-beta2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
biological term
0.96
gene perturbation
0.96
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2239.49   (req: < 5)
Gene RIFs: 207   (req: <= 3)
Antibodies: 528   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2239.49   (req: >= 5)
Gene RIFs: 207   (req: > 3)
Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0