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Tbio
TGFB1I1
Transforming growth factor beta-1-induced transcript 1 protein

Protein Summary
Description
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361773
  • ENSP00000355117
  • ENSG00000140682
  • ENST00000394858
  • ENSP00000378327
  • ENST00000394863
  • ENSP00000378332
  • ENST00000567607
  • ENSP00000457586

Symbol
  • ARA55
  • HIC5
  • ARA55
  • HIC-5
  • TSC-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
biological process
0.92
PubMedID
0.84
gene perturbation
0.76
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.53   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.53   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
PTK2B
Tclin
Family:  Kinase
Novelty:  0.00174314
Score:  0.983
Data Source:  STRINGDB
PTK2
Tclin
Family:  Kinase
Novelty:  0.00066622
Score:  0.962
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.901
Data Source:  STRINGDB
BCAR1
Tbio
Novelty:  0.00329214
Score:  0.889
Data Source:  STRINGDB
PARVA
Tbio
Novelty:  0.02736601
Score:  0.885
Data Source:  STRINGDB
NEDD9
Tbio
Novelty:  0.00539079
Score:  0.852
Data Source:  STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.845
Data Source:  STRINGDB
PARVB
Tbio
Novelty:  0.03825772
Score:  0.839
Data Source:  STRINGDB
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
Score:  0.821
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.799
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (113)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Angiogenesis
PathwayCommons: panther
VEGF signaling pathway
PathwayCommons: pid
Coregulation of Androgen receptor activity
PathwayCommons: netpath
AndrogenReceptor
Name
Explore in Pharos
Explore in Source
Angiogenesis
VEGF signaling pathway
Coregulation of Androgen receptor activity
AndrogenReceptor
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Glycosuria
5
3
0
4.1
77.2
red blood cell distribution width
4
1
4
47.7
reticulocyte measurement
2
1
2
34.9
reticulocyte count
2
1
2
28
fetal genotype effect measurement
1
1
0
7.8
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Glycosuria
0
4.1
77.2
red blood cell distribution width
4
47.7
reticulocyte measurement
2
34.9
reticulocyte count
2
28
fetal genotype effect measurement
0
7.8
24.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta 1 induced transcript 1
VGNC:5933
467962
Macaque
transforming growth factor beta 1 induced transcript 1
714172
Mouse
MGI:102784
21804
Rat
RGD:620173
84574
Dog
transforming growth factor beta 1 induced transcript 1
VGNC:47308
489932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta 1 induced transcript 1
Macaque
transforming growth factor beta 1 induced transcript 1
Mouse
Rat
Dog
transforming growth factor beta 1 induced transcript 1
Publication Statistics
PubMed Score 109.53
PubMed score by year
PubTator Score 77.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title