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Tbio
TGDS
dTDP-D-glucose 4,6-dehydratase

Protein Summary
Description
The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261296
  • ENSP00000261296
  • ENSG00000088451

Symbol
  • TDPGD
  • SDR2E1
  • CATMANS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor binding site profile
0.71
tissue sample
0.59
cellular component
0.57
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.69   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.69   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999883696
p_ni:  0.000115187
p_wrong:  0.000001117
Score:  0.188
Data Source:  BioPlex,STRINGDB
MTF2
Tbio
Family:  Epigenetic
Novelty:  0.01152147
p_int:  0.999804708
p_ni:  0.00017971
p_wrong:  0.000015582
Score:  0.252
Data Source:  BioPlex,STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
p_int:  0.997550658
p_ni:  0.001154403
p_wrong:  0.001294939
Score:  0.309
Data Source:  BioPlex,STRINGDB
TCAF1
Tbio
Family:  Enzyme
Novelty:  0.50366212
p_int:  0.818628686
p_ni:  0.181371314
Score:  0.332
Data Source:  BioPlex,STRINGDB
GPR180
Tbio
Novelty:  0.03378902
Score:  0.757
Data Source:  STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
Score:  0.689
Data Source:  STRINGDB
UGDH
Tbio
Family:  Enzyme
Novelty:  0.00284931
Score:  0.678
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.59
Data Source:  STRINGDB
USP9X
Tbio
Family:  Enzyme
Novelty:  0.00820155
Score:  0.587
Data Source:  STRINGDB
GALE
Tchem
Family:  Enzyme
Novelty:  0.00256798
Score:  0.585
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
7
9
94.9
alkaline phosphatase measurement
3
3
2
15.2
93.8
sex hormone-binding globulin measurement
7
2
6
6.3
87.8
hair colour measurement
1
1
1
59
free cholesterol:total lipids ratio
3
2
3
53.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
94.9
alkaline phosphatase measurement
2
15.2
93.8
sex hormone-binding globulin measurement
6
6.3
87.8
hair colour measurement
1
59
free cholesterol:total lipids ratio
3
53.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TDP-glucose 4,6-dehydratase
VGNC:13228
467299
Macaque
TDP-glucose 4,6-dehydratase
694721
Mouse
MGI:1923605
76355
Dog
TDP-glucose 4,6-dehydratase
VGNC:47307
485521
Horse
TDP-glucose 4,6-dehydratase
VGNC:24050
100058960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TDP-glucose 4,6-dehydratase
Macaque
TDP-glucose 4,6-dehydratase
Mouse
Dog
TDP-glucose 4,6-dehydratase
Horse
TDP-glucose 4,6-dehydratase
Publication Statistics
PubMed Score 67.69
PubMed score by year
PubTator Score 9.57
PubTator score by year
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Related Publications
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PMID
Year
Title