Protein Summary
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
- ENST00000220616
- ENSP00000220616
- ENSG00000042832
- TGN
- AITD3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.86 | ||
protein domain | 0.85 | ||
disease | 0.78 | ||
gene perturbation | 0.69 | ||
cell line | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9740.1 (req: < 5)
Gene RIFs: 120 (req: <= 3)
Antibodies: 1645 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9740.1 (req: >= 5)
Gene RIFs: 120 (req: > 3)
Antibodies: 1645 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (142)
Nearest Tclin Targets
Pathways (4)
KEGG (2)
PathwayCommons (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Autoimmune thyroid disease | ||||
KEGG | Thyroid hormone synthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autoimmune thyroid disease | ||||
Thyroid hormone synthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (1)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Thyroid preparation use measurement | 1 | 2 | 2 | 71.1 | |||||
2 | 2 | 0 | 1.2 | 70.4 | |||||
autoimmune thyroid disease | 1 | 2 | 0 | 1.1 | 67.5 | ||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 45.7 | |||||
mathematical ability | 1 | 1 | 1 | 45.2 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Thyroid preparation use measurement | 2 | 71.1 | |||||
0 | 1.2 | 70.4 | |||||
autoimmune thyroid disease | 0 | 1.1 | 67.5 | ||||
eosinophil percentage of leukocytes | 1 | 45.7 | |||||
mathematical ability | 1 | 45.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thyroglobulin | VGNC:14597 | 464407 | |||||
Mouse | MGI:98733 | 21819 | ||||||
Rat | RGD:3848 | 24826 | ||||||
Dog | thyroglobulin | VGNC:47306 | 482047 | |||||
Horse | thyroglobulin | VGNC:24049 | 100058029 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thyroglobulin | |||||
Mouse | ||||||
Rat | ||||||
Dog | thyroglobulin | |||||
Horse | thyroglobulin | |||||
Publication Statistics
PubMed Score 9740.10
PubMed score by year
PubTator Score 2756.40
PubTator score by year
Related Publications
Text Mined References (173)
GeneRif Annotations (120)
Items per page:
0 of 0
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