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Tbio
TFR2
Transferrin receptor protein 2

Protein Summary
Description
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223051
  • ENSP00000223051
  • ENSG00000106327
  • ENST00000462107
  • ENSP00000420525

Symbol
  • HFE3
  • TFRC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
biological term
0.68
disease
0.61
kinase perturbation
0.6
cellular component
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.69   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.69   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
LRRFIP1
Tbio
Novelty:  0.02584638
p_int:  0.999220004
p_ni:  0.000779996
Score:  0.232
Data Source:  BioPlex,STRINGDB
TAF5L
Tbio
Family:  Enzyme
Novelty:  0.29525944
p_int:  0.927560863
p_ni:  0.072438771
p_wrong:  3.66e-7
Data Source:  BioPlex
GLG1
Tbio
Novelty:  0.01332149
p_int:  0.920650225
p_ni:  0.079349775
Data Source:  BioPlex
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.891357303
p_ni:  0.104178118
p_wrong:  0.004464578
Data Source:  BioPlex
GALNT12
Tbio
Family:  Enzyme
Novelty:  0.085131
p_int:  0.865023876
p_ni:  0.134973688
p_wrong:  0.000002436
Data Source:  BioPlex
EXT1
Tbio
Family:  Enzyme
Novelty:  0.00355951
p_int:  0.838470005
p_ni:  0.16152999
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
MAD2L2
Tbio
Novelty:  0.01091072
p_int:  0.796990769
p_ni:  0.203009229
p_wrong:  3e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
PFKL
Tbio
Family:  Kinase
Novelty:  0.00586306
p_int:  0.762626566
p_ni:  0.237373434
Score:  0.365
Data Source:  BioPlex,STRINGDB
PDF
Tchem
Family:  Enzyme
Novelty:  0.02477934
p_int:  0.760616252
p_ni:  0.239383748
Score:  0.206
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Iron uptake and transport (R-HSA-917937)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Transferrin endocytosis and recycling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Transferrin endocytosis and recycling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
8
14
18
99.7
hemoglobin measurement
4
10
15
99.5
red blood cell distribution width
4
5
9
99
mean corpuscular hemoglobin concentration
5
4
5
98.9
erythrocyte count
6
5
8
98.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
18
99.7
hemoglobin measurement
15
99.5
red blood cell distribution width
9
99
mean corpuscular hemoglobin concentration
5
98.9
erythrocyte count
8
98.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transferrin receptor 2
VGNC:4535
463605
Mouse
MGI:1354956
50765
Rat
RGD:1310152
288562
Dog
transferrin receptor 2
VGNC:47304
489834
Horse
transferrin receptor 2
VGNC:24047
100067467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transferrin receptor 2
Mouse
Rat
Dog
transferrin receptor 2
Horse
transferrin receptor 2
Publication Statistics
PubMed Score 197.69
PubMed score by year
PubTator Score 161.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title