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Tbio
TFPT
TCF3 fusion partner

Protein Summary
Description
Appears to promote apoptosis in a p53/TP53-independent manner. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391758
  • ENSP00000375638
  • ENSG00000105619
  • ENST00000391759
  • ENSP00000375639
  • ENST00000611344
  • ENSP00000484338
  • ENSG00000276504
  • ENST00000616798
  • ENSP00000480169

Symbol
  • INO80F
  • FB1
  • amida
  • INO80F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
histone modification site profile
0.92
kinase perturbation
0.81
transcription factor binding site profile
0.77
cellular component
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.71   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.71   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.999998294
p_ni:  0.000001698
p_wrong:  7e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.999995136
p_ni:  0.000003847
p_wrong:  0.000001017
Score:  0.95
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999977383
p_ni:  0.000013131
p_wrong:  0.000009486
Data Source:  BioPlex
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999971071
p_ni:  0.000026628
p_wrong:  0.000002301
Score:  0.953
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.999960402
p_ni:  0.000035247
p_wrong:  0.000004351
Score:  0.953
Data Source:  BioPlex,STRINGDB
CCNDBP1
Tbio
Novelty:  0.01527762
p_int:  0.999910668
p_ni:  0.000071034
p_wrong:  0.000018297
Score:  0.775
Data Source:  BioPlex,STRINGDB
INO80
Tbio
Family:  Enzyme
Novelty:  0.09412936
p_int:  0.998127221
p_ni:  0.001666195
p_wrong:  0.000206584
Score:  0.921
Data Source:  BioPlex,STRINGDB
INO80C
Tdark
Novelty:  0.04242834
p_int:  0.992202013
p_ni:  0.007793943
p_wrong:  0.000004044
Score:  0.902
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.922281775
p_ni:  0.000095463
p_wrong:  0.077622762
Data Source:  BioPlex
INO80E
Tdark
Novelty:  0.38735443
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (138)
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
blood metabolite measurement
2
2
2
89.9
blood metabolite measurement
2
2
2
89.9
phosphatidylinositol measurement
1
1
3
78.4
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
blood metabolite measurement
2
89.9
blood metabolite measurement
2
89.9
phosphatidylinositol measurement
3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TCF3 fusion partner
VGNC:14757
107969803
Macaque
TCF3 fusion partner
720296
Mouse
MGI:1916964
69714
Rat
RGD:620839
85423
Dog
TCF3 fusion partner
VGNC:47303
611475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TCF3 fusion partner
Macaque
TCF3 fusion partner
Mouse
Rat
Dog
TCF3 fusion partner
Publication Statistics
PubMed Score 10.71
PubMed score by year
PubTator Score 121.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title