Tbio TFPT TCF3 fusion partner

Protein Summary

Description

Appears to promote apoptosis in a p53/TP53-independent manner. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Uniprot Accession IDs

• P0C1Z6
• G5E9B5

Gene Name

• TFPT

Ensembl ID

• ENST00000391758
• ENSP00000375638
• ENSG00000105619
• ENST00000391759
• ENSP00000375639
• ENST00000611344
• ENSP00000484338
• ENSG00000276504
• ENST00000616798
• ENSP00000480169

Symbol

• INO80F
• FB1
• amida
• INO80F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
histone modification site profile	0.92
kinase perturbation	0.81
transcription factor binding site profile	0.77
cellular component	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.71   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.71   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

LRRC46

Tdark

Novelty:  1.159245

p_int:  0.999998294

p_ni:  0.000001698

p_wrong:  7e-9

Score:  0.173

Data Source:  BioPlex,STRINGDB

UCHL5

Tbio

Family:  Enzyme

Novelty:  0.01486265

p_int:  0.999995136

p_ni:  0.000003847

p_wrong:  0.000001017

Score:  0.95

Data Source:  BioPlex,STRINGDB

SGF29

Tbio

Family:  Epigenetic

Novelty:  0.0426456

p_int:  0.999977383

p_ni:  0.000013131

p_wrong:  0.000009486

Data Source:  BioPlex

RUVBL1

Tbio

Novelty:  0.0089115

p_int:  0.999971071

p_ni:  0.000026628

p_wrong:  0.000002301

Score:  0.953

Data Source:  BioPlex,STRINGDB

RUVBL2

Tbio

Novelty:  0.01129017

p_int:  0.999960402

p_ni:  0.000035247

p_wrong:  0.000004351

Score:  0.953

Data Source:  BioPlex,STRINGDB

CCNDBP1

Tbio

Novelty:  0.01527762

p_int:  0.999910668

p_ni:  0.000071034

p_wrong:  0.000018297

Score:  0.775

Data Source:  BioPlex,STRINGDB

INO80

Tbio

Family:  Enzyme

Novelty:  0.09412936

p_int:  0.998127221

p_ni:  0.001666195

p_wrong:  0.000206584

Score:  0.921

Data Source:  BioPlex,STRINGDB

INO80C

Tdark

Novelty:  0.04242834

p_int:  0.992202013

p_ni:  0.007793943

p_wrong:  0.000004044

Score:  0.902

Data Source:  BioPlex,STRINGDB

RALBP1

Tbio

Novelty:  0.01525176

p_int:  0.922281775

p_ni:  0.000095463

p_wrong:  0.077622762

Data Source:  BioPlex

INO80E

Tdark

Novelty:  0.38735443

Score:  0.949

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (8)

DNA Damage Recognition in GG-NER (R-HSA-5696394)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Deubiquitination	278 targets	R-HSA-5688426
Reactome	Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
DNA Repair	306 targets	R-HSA-73894
Deubiquitination	278 targets	R-HSA-5688426
Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (1)

Components (5)

Processes (5)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (138)

Items per page:

5

1 – 5 of 138

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	ENSG00000276504	2	3	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	ENSG00000105619	2	3	3	18.1	97.7
blood metabolite measurement	EFO_0005664	ENSG00000105619	2	2	2		89.9
blood metabolite measurement	EFO_0005664	ENSG00000276504	2	2	2		89.9
phosphatidylinositol measurement	EFO_0010230	ENSG00000276504	1	1	3		78.4

Items per page:

5

1 – 5 of 138

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
blood metabolite measurement	EFO_0005664	2		89.9
blood metabolite measurement	EFO_0005664	2		89.9
phosphatidylinositol measurement	EFO_0010230	3		78.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Apoptosis
Chromosomal rearrangement
Complete proteome
DNA damage
DNA recombination
DNA repair
Isopeptide bond
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
adiponectin measurement
alcoholic liver cirrhosis
alkaline phosphatase measurement
amino acid measurement
antioxidant measurement
arm span
asparaginase hypersensitivity
aspartate aminotransferase measurement
birth weight
blood metabolite measurement

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	TCF3 fusion partner	VGNC:14757	107969803
Macaque	TCF3 fusion partner		720296
Mouse	TCF3 (E2A) fusion partner	MGI:1916964	69714
Rat	TCF3 fusion partner	RGD:620839	85423
Dog	TCF3 fusion partner	VGNC:47303	611475

Species	Name	OMA	EggNOG	Inparanoid
Chimp	TCF3 fusion partner
Macaque	TCF3 fusion partner
Mouse	TCF3 (E2A) fusion partner
Rat	TCF3 fusion partner
Dog	TCF3 fusion partner

Publication Statistics

PubMed Score 10.71

PubMed score by year

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PubTator Score 121.69

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (4)

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PMID	Year	Title