Protein Summary
Appears to promote apoptosis in a p53/TP53-independent manner. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
- ENST00000391758
- ENSP00000375638
- ENSG00000105619
- ENST00000391759
- ENSP00000375639
- ENST00000611344
- ENSP00000484338
- ENSG00000276504
- ENST00000616798
- ENSP00000480169
- INO80F
- FB1
- amida
- INO80F
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
ligand (protein) perturbation | 0.96 | ||
histone modification site profile | 0.92 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.77 | ||
cellular component | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.71 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.71 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
LRRC46
Novelty: 1.159245
p_int: 0.999998294
p_ni: 0.000001698
p_wrong: 7e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
UCHL5
Family: Enzyme
Novelty: 0.01486265
p_int: 0.999995136
p_ni: 0.000003847
p_wrong: 0.000001017
Score: 0.95
Data Source: BioPlex,STRINGDB
SGF29
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.999977383
p_ni: 0.000013131
p_wrong: 0.000009486
Data Source: BioPlex
RUVBL1
Novelty: 0.0089115
p_int: 0.999971071
p_ni: 0.000026628
p_wrong: 0.000002301
Score: 0.953
Data Source: BioPlex,STRINGDB
RUVBL2
Novelty: 0.01129017
p_int: 0.999960402
p_ni: 0.000035247
p_wrong: 0.000004351
Score: 0.953
Data Source: BioPlex,STRINGDB
CCNDBP1
Novelty: 0.01527762
p_int: 0.999910668
p_ni: 0.000071034
p_wrong: 0.000018297
Score: 0.775
Data Source: BioPlex,STRINGDB
INO80
Family: Enzyme
Novelty: 0.09412936
p_int: 0.998127221
p_ni: 0.001666195
p_wrong: 0.000206584
Score: 0.921
Data Source: BioPlex,STRINGDB
INO80C
Novelty: 0.04242834
p_int: 0.992202013
p_ni: 0.007793943
p_wrong: 0.000004044
Score: 0.902
Data Source: BioPlex,STRINGDB
RALBP1
Novelty: 0.01525176
p_int: 0.922281775
p_ni: 0.000095463
p_wrong: 0.077622762
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | DNA Damage Recognition in GG-NER | ||||
Reactome | DNA Repair | ||||
Reactome | Deubiquitination | ||||
Reactome | Global Genome Nucleotide Excision Repair (GG-NER) | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DNA Damage Recognition in GG-NER | ||||
DNA Repair | ||||
Deubiquitination | ||||
Global Genome Nucleotide Excision Repair (GG-NER) | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (138)
Items per page:
1 – 5 of 138
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 2 | 3 | 3 | 18.1 | 97.7 | |||||
alkaline phosphatase measurement | 2 | 3 | 3 | 18.1 | 97.7 | |||||
blood metabolite measurement | 2 | 2 | 2 | 89.9 | ||||||
blood metabolite measurement | 2 | 2 | 2 | 89.9 | ||||||
phosphatidylinositol measurement | 1 | 1 | 3 | 78.4 | ||||||
Items per page:
1 – 5 of 138
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 3 | 18.1 | 97.7 | ||||
alkaline phosphatase measurement | 3 | 18.1 | 97.7 | ||||
blood metabolite measurement | 2 | 89.9 | |||||
blood metabolite measurement | 2 | 89.9 | |||||
phosphatidylinositol measurement | 3 | 78.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | TCF3 fusion partner | VGNC:14757 | 107969803 | |||||
Macaque | TCF3 fusion partner | 720296 | ||||||
Mouse | MGI:1916964 | 69714 | ||||||
Rat | RGD:620839 | 85423 | ||||||
Dog | TCF3 fusion partner | VGNC:47303 | 611475 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | TCF3 fusion partner | |||||
Macaque | TCF3 fusion partner | |||||
Mouse | ||||||
Rat | ||||||
Dog | TCF3 fusion partner | |||||
Publication Statistics
PubMed Score 10.71
PubMed score by year
PubTator Score 121.69
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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