Protein Summary
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
- ENST00000240851
- ENSP00000240851
- ENSG00000114354
- ENST00000418917
- ENSP00000397182
- ENST00000476228
- ENSP00000417952
- ENST00000490574
- ENSP00000419960
- ENST00000615993
- ENSP00000479269
- ENST00000620299
- ENSP00000479981
- TF6
- HMSNP
- SPG57
- TRKT3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.96 | ||
disease perturbation | 0.9 | ||
drug perturbation | 0.87 | ||
transcription factor perturbation | 0.84 | ||
hub protein | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 96.78 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 278 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 96.78 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 278 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0