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Tbio
TFF1
Trefoil factor 1

Protein Summary
Description
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291527
  • ENSP00000291527
  • ENSG00000160182

Symbol
  • BCEI
  • PS2
  • pS2
  • BCEI
  • HPS2
  • HP1.A
  • pNR-2
  • D21S21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
biological term
0.81
chemical
0.66
gene perturbation
0.66
small molecule perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.58   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 838   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.58   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 838   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.987
Data Source:  STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.97
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.97
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.963
Data Source:  STRINGDB
ERBB2
Tclin
Family:  Kinase
Novelty:  0.00003761
Score:  0.948
Data Source:  STRINGDB
TFF3
Tbio
Novelty:  0.00127103
Score:  0.944
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.939
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.939
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.931
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
89.7
2
2
0
1.2
76.7
1
2
0
1.2
66.6
eosinophil count
2
1
2
64.9
lymphocyte count
2
1
2
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
89.7
0
1.2
76.7
0
1.2
66.6
eosinophil count
2
64.9
lymphocyte count
2
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trefoil factor 1
VGNC:1121
100613424
Mouse
MGI:88135
21784
Rat
RGD:620707
117270
Dog
trefoil factor 1
VGNC:47296
403491
Horse
trefoil factor 1
VGNC:24041
100629635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trefoil factor 1
Mouse
Rat
Dog
trefoil factor 1
Horse
trefoil factor 1
Publication Statistics
PubMed Score 358.58
PubMed score by year
PubTator Score 411.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title