Tbio TFCP2 Alpha-globin transcription factor CP2

Protein Summary

Description

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q12800
• A8K5E9
• Q12801
• Q9UD75
• Q9UD77

Gene Name

• TFCP2

Ensembl ID

• ENST00000257915
• ENSP00000257915
• ENSG00000135457
• ENST00000548115
• ENSP00000447991

Symbol

• LSF
• SEF
• LSF
• SEF
• LBP1C
• LSF1D
• TFCP2C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
hub protein	0.75
virus perturbation	0.72
histone modification site profile	0.7
transcription factor binding site profile	0.64

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Alpha-globin Transcription Factor Cp2

DTO Classes

Protein / Transcription Factor / Alpha-globin Transcription Factor Cp2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.59   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.59   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0