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Tbio
TFCP2
Alpha-globin transcription factor CP2

Protein Summary
Description
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257915
  • ENSP00000257915
  • ENSG00000135457
  • ENST00000548115
  • ENSP00000447991

Symbol
  • LSF
  • SEF
  • LSF
  • SEF
  • LBP1C
  • LSF1D
  • TFCP2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
hub protein
0.75
virus perturbation
0.72
histone modification site profile
0.7
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.48   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.48   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  1
Score:  0.84
Data Source:  BioPlex,STRINGDB
TFCP2L1
Tbio
Family:  TF
Novelty:  0.04097991
p_int:  1
Score:  0.513
Data Source:  BioPlex,STRINGDB
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
p_int:  0.999976692
p_ni:  0.000023308
Score:  0.188
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.99969389
p_ni:  0.00030611
Data Source:  BioPlex
PRMT6
Tchem
Family:  Epigenetic
Novelty:  0.01734208
p_int:  0.999175525
p_ni:  0.000824475
Score:  0.563
Data Source:  BioPlex,STRINGDB
ANKRD29
Tdark
Novelty:  1.29202649
p_int:  0.99516341
p_ni:  0.00483659
Score:  0.686
Data Source:  BioPlex,STRINGDB
BRD4
Tchem
Family:  Epigenetic
Novelty:  0.0013933
p_int:  0.990794322
p_ni:  0.009205147
p_wrong:  5.31e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
p_int:  0.973548898
p_ni:  0.026451101
Score:  0.723
Data Source:  BioPlex,STRINGDB
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.969609255
p_ni:  0.030382849
p_wrong:  0.000007895
Data Source:  BioPlex
STK35
Tchem
Family:  Kinase
Novelty:  0.19556072
p_int:  0.956403824
p_ni:  0.043596176
Score:  0.552
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
51.4
platelet count
1
1
1
44.2
body height
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
51.4
platelet count
1
44.2
body height
1
26.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor CP2
VGNC:5620
450171
Macaque
transcription factor CP2
574399
Mouse
MGI:98509
21422
Rat
RGD:1306738
315309
Dog
transcription factor CP2
VGNC:47290
477607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor CP2
Macaque
transcription factor CP2
Mouse
Rat
Dog
transcription factor CP2
Publication Statistics
PubMed Score 171.48
PubMed score by year
PubTator Score 75.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title