Tbio TFB2M Dimethyladenosine transferase 2, mitochondrial

Protein Summary

Description

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.

Uniprot Accession IDs

• Q9H5Q4
• Q9H626

Gene Name

• TFB2M

Ensembl ID

• ENST00000366514
• ENSP00000355471
• ENSG00000162851

Symbol

• NS5ATP5
• Hkp1
• mtTFB2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
interacting protein	0.85
histone modification site profile	0.73
transcription factor binding site profile	0.73
molecular function	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Rna Methyltransferase / Dimethyladenosine Transferase 2, Mitochondrial

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Methyltransferase / Dimethyladenosine Transferase 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.06   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.06   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0