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Tbio
TFAP4
Transcription factor AP-4

Protein Summary
Description
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204517
  • ENSP00000204517
  • ENSG00000090447

Symbol
  • BHLHC41
  • AP-4
  • bHLHc41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.97
transcription factor binding site profile
0.97
histone modification site profile
0.8
transcription factor
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.52   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.52   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
BTRC
Tbio
Novelty:  0.00293475
p_int:  1
Score:  0.371
Data Source:  BioPlex,STRINGDB
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
p_int:  0.999989096
p_ni:  0.000010904
Data Source:  BioPlex
ANGPTL7
Tbio
Novelty:  0.03893082
p_int:  0.999985333
p_ni:  0.000014667
Data Source:  BioPlex
HIRA
Tbio
Novelty:  0.01362595
p_int:  0.99997226
p_ni:  0.000027739
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
NEU2
Tbio
Family:  Enzyme
Novelty:  0.00460828
p_int:  0.99992352
p_ni:  0.000076395
p_wrong:  8.4e-8
Score:  0.534
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999802169
p_ni:  0.000193148
p_wrong:  0.000004683
Score:  0.336
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.99967603
p_ni:  0.00032397
Score:  0.336
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999636805
p_ni:  0.000362226
p_wrong:  9.69e-7
Data Source:  BioPlex
CABIN1
Tbio
Novelty:  0.02528794
p_int:  0.999537686
p_ni:  0.000462314
Score:  0.175
Data Source:  BioPlex,STRINGDB
UBN2
Tbio
Novelty:  0.09777456
p_int:  0.99938627
p_ni:  0.000613378
p_wrong:  3.52e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
8
9
94.9
BMI-adjusted hip circumference
2
11
12
92.5
hip circumference
1
5
5
87.5
waist-hip ratio
2
6
6
84.2
mean corpuscular hemoglobin concentration
1
1
1
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
94.9
BMI-adjusted hip circumference
12
92.5
hip circumference
5
87.5
waist-hip ratio
6
84.2
mean corpuscular hemoglobin concentration
1
77.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-4
VGNC:13798
748090
Mouse
MGI:103239
83383
Rat
RGD:1308357
360482
Dog
transcription factor AP-4
VGNC:47287
490029
Horse
transcription factor AP-4
VGNC:24032
100069711
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-4
Mouse
Rat
Dog
transcription factor AP-4
Horse
transcription factor AP-4
Publication Statistics
PubMed Score 39.52
PubMed score by year
PubTator Score 156.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title