Tbio TFAP4 Transcription factor AP-4

Protein Summary

Description

Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

Uniprot Accession IDs

• Q01664
• O60409

Gene Name

• TFAP4

Ensembl ID

• ENST00000204517
• ENSP00000204517
• ENSG00000090447

Symbol

• BHLHC41
• AP-4
• bHLHc41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
molecular function	0.97
transcription factor binding site profile	0.97
histone modification site profile	0.8
transcription factor	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.52   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 298   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.52   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (55)

Explore Interacting Targets

1 – 10 of 55

• See Interactions on String-DB

BTRC

Tbio

Novelty:  0.00293475

p_int:  1

Score:  0.371

Data Source:  BioPlex,STRINGDB

ADAMTS4

Tchem

Family:  Enzyme

Novelty:  0.00424194

p_int:  0.999989096

p_ni:  0.000010904

Data Source:  BioPlex

ANGPTL7

Tbio

Novelty:  0.03893082

p_int:  0.999985333

p_ni:  0.000014667

Data Source:  BioPlex

HIRA

Tbio

Novelty:  0.01362595

p_int:  0.99997226

p_ni:  0.000027739

p_wrong:  1e-9

Score:  0.181

Data Source:  BioPlex,STRINGDB

NEU2

Tbio

Family:  Enzyme

Novelty:  0.00460828

p_int:  0.99992352

p_ni:  0.000076395

p_wrong:  8.4e-8

Score:  0.534

Data Source:  BioPlex,STRINGDB

SKP1

Tbio

Family:  Enzyme

Novelty:  0.00149739

p_int:  0.999802169

p_ni:  0.000193148

p_wrong:  0.000004683

Score:  0.336

Data Source:  BioPlex,STRINGDB

FBXW11

Tbio

Novelty:  0.0715377

p_int:  0.99967603

p_ni:  0.00032397

Score:  0.336

Data Source:  BioPlex,STRINGDB

STN1

Tbio

Novelty:  0.01309587

p_int:  0.999636805

p_ni:  0.000362226

p_wrong:  9.69e-7

Data Source:  BioPlex

CABIN1

Tbio

Novelty:  0.02528794

p_int:  0.999537686

p_ni:  0.000462314

Score:  0.175

Data Source:  BioPlex,STRINGDB

UBN2

Tbio

Novelty:  0.09777456

p_int:  0.99938627

p_ni:  0.000613378

p_wrong:  3.52e-7

Score:  0.195

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (2)

1 – 2 of 2

ERBB2

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Proteoglycans in cancer

ERBB4

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Proteoglycans in cancer

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Proteoglycans in cancer	201 targets	path:hsa05205

Name	Explore in Pharos	Explore in Source
Proteoglycans in cancer	201 targets	path:hsa05205

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (10)

Components (3)

Processes (15)

Find Similar Targets

Items per page:

10

1 – 10 of 10

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
E-box binding	Inferred from Direct Assay (IDA)	UniProtKB
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
histone deacetylase binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
DNA-binding transcription factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (20)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	4	8	9		94.9
BMI-adjusted hip circumference	EFO_0008039	2	11	12		92.5
hip circumference	EFO_0005093	1	5	5		87.5
waist-hip ratio	EFO_0004343	2	6	6		84.2
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		77.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	9		94.9
BMI-adjusted hip circumference	EFO_0008039	12		92.5
hip circumference	EFO_0005093	5		87.5
waist-hip ratio	EFO_0004343	6		84.2
mean corpuscular hemoglobin concentration	EFO_0004528	1		77.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Complete proteome
Direct protein sequencing
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
balding measurement
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
central corneal thickness
electrocardiography
FEV/FEC ratio
HbA1c measurement
heel bone mineral density
hip circumference

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
nervous system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transcription factor AP-4	VGNC:13798	748090
Mouse	transcription factor AP4	MGI:103239	83383
Rat	transcription factor AP-4	RGD:1308357	360482
Dog	transcription factor AP-4	VGNC:47287	490029
Horse	transcription factor AP-4	VGNC:24032	100069711

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transcription factor AP-4
Mouse	transcription factor AP4
Rat	transcription factor AP-4
Dog	transcription factor AP-4
Horse	transcription factor AP-4

Publication Statistics

PubMed Score 39.52

PubMed score by year

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PubTator Score 156.87

PubTator score by year

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Related Publications

Text Mined References (41)

GeneRif Annotations (22)

Items per page:

10

0 of 0

PMID	Year	Title