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Tdark
TFAP2D
Transcription factor AP-2-delta

Protein Summary
Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000008391
  • ENSP00000008391
  • ENSG00000008197

Symbol
  • TFAP2BL1
  • TFAP2BL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
cell line
0.64
biological process
0.63
molecular function
0.56
virus perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.54   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.54   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.96
Data Source:  STRINGDB
KCTD1
Tbio
Novelty:  0.09964774
Score:  0.926
Data Source:  STRINGDB
KCTD15
Tbio
Novelty:  0.05277304
Score:  0.926
Data Source:  STRINGDB
TFAP2E
Tbio
Family:  TF
Novelty:  0.07487225
Score:  0.919
Data Source:  STRINGDB
TFAP2B
Tbio
Family:  TF
Novelty:  0.01383202
Score:  0.919
Data Source:  STRINGDB
TFAP2C
Tbio
Family:  TF
Novelty:  0.00893737
Score:  0.919
Data Source:  STRINGDB
CITED2
Tbio
Novelty:  0.01028104
Score:  0.918
Data Source:  STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
Score:  0.904
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.902
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
6
18
1.2
98.7
5
3
3
1.1
89.1
comparative body size at age 10, self-reported
1
1
1
83
visceral adipose tissue measurement
1
2
2
81.2
waist-hip ratio
3
2
3
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
18
1.2
98.7
3
1.1
89.1
comparative body size at age 10, self-reported
1
83
visceral adipose tissue measurement
2
81.2
waist-hip ratio
3
75
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 delta
VGNC:13039
472026
Macaque
transcription factor AP-2 delta
707582
Mouse
MGI:2153466
226896
Dog
transcription factor AP-2 delta
VGNC:47286
481835
Horse
transcription factor AP-2 delta
VGNC:24031
100056165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 delta
Macaque
transcription factor AP-2 delta
Mouse
Dog
transcription factor AP-2 delta
Horse
transcription factor AP-2 delta
Publication Statistics
PubMed Score 4.54
PubMed score by year
PubTator Score 8.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title