You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TFAP2C
Transcription factor AP-2 gamma

Protein Summary
Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000201031
  • ENSP00000201031
  • ENSG00000087510

Symbol
  • ERF1
  • TFAP2G
  • hAP-2g
  • AP2-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
gene perturbation
0.88
molecular function
0.88
biological process
0.87
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.7   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.7   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
KCTD1
Tbio
Novelty:  0.09964774
Score:  0.991
Data Source:  Reactome,STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.979
Data Source:  STRINGDB
CITED2
Tbio
Novelty:  0.01028104
Score:  0.967
Data Source:  Reactome,STRINGDB
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
Score:  0.957
Data Source:  Reactome,STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.956
Data Source:  Reactome,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.951
Data Source:  STRINGDB
CITED1
Tbio
Novelty:  0.01956689
Score:  0.949
Data Source:  STRINGDB
CITED4
Tbio
Novelty:  0.08663668
Score:  0.947
Data Source:  Reactome,STRINGDB
KCTD15
Tbio
Novelty:  0.05277304
Score:  0.947
Data Source:  Reactome,STRINGDB
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.945
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
1
1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
8.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 gamma
VGNC:10007
747174
Macaque
transcription factor AP-2 gamma
705384
Mouse
MGI:106032
21420
Rat
RGD:1303185
362280
Dog
transcription factor AP-2 gamma
VGNC:47285
485941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 gamma
Macaque
transcription factor AP-2 gamma
Mouse
Rat
Dog
transcription factor AP-2 gamma
Publication Statistics
PubMed Score 117.70
PubMed score by year
PubTator Score 63.95
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title