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Tbio
TFAP2B
Transcription factor AP-2-beta

Protein Summary
Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393655
  • ENSP00000377265
  • ENSG00000008196

Symbol
  • PDA2
  • AP-2B
  • AP2-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
gene perturbation
0.84
PubMedID
0.81
phenotype
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.78   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.78   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
EIF5A2
Tbio
Novelty:  0.01527502
p_int:  0.996595965
p_wrong:  0.003404035
Data Source:  BioPlex
AK4
Tbio
Family:  Kinase
Novelty:  0.00977619
p_int:  0.991602769
p_ni:  0.006019137
p_wrong:  0.002378094
Data Source:  BioPlex
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.947224966
p_ni:  0.052774989
p_wrong:  4.5e-8
Data Source:  BioPlex
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
p_int:  0.899749783
p_ni:  4.9e-8
p_wrong:  0.100250168
Score:  0.949
Data Source:  BioPlex,Reactome,STRINGDB
KCTD1
Tbio
Novelty:  0.09964774
Score:  0.989
Data Source:  Reactome,STRINGDB
KCTD15
Tbio
Novelty:  0.05277304
Score:  0.981
Data Source:  Reactome,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
Score:  0.965
Data Source:  Reactome,STRINGDB
CITED2
Tbio
Novelty:  0.01028104
Score:  0.963
Data Source:  Reactome,STRINGDB
CITED1
Tbio
Novelty:  0.01956689
Score:  0.946
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.937
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (111)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (59)
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Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
18
8
32
1.2
98.9
5
3
3
1.1
89.1
comparative body size at age 10, self-reported
1
1
1
83
visceral adipose tissue measurement
1
2
2
81.2
physical activity measurement
1
3
6
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
32
1.2
98.9
3
1.1
89.1
comparative body size at age 10, self-reported
1
83
visceral adipose tissue measurement
2
81.2
physical activity measurement
6
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 beta
VGNC:13037
462758
Macaque
transcription factor AP-2 beta
707679
Mouse
MGI:104672
21419
Rat
RGD:1306321
301285
Dog
transcription factor AP-2 beta
VGNC:47284
403463
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 beta
Macaque
transcription factor AP-2 beta
Mouse
Rat
Dog
transcription factor AP-2 beta
Publication Statistics
PubMed Score 73.78
PubMed score by year
PubTator Score 95.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title