Tbio TFAM Transcription factor A, mitochondrial

Protein Summary

Description

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q00059
• A8MRB2
• A9QXC6
• B5BU05
• Q5U0C6
• mtTFA

Gene Name

• TFAM

Ensembl ID

• ENST00000373895
• ENSP00000363002
• ENSG00000108064
• ENST00000487519
• ENSP00000420588

Symbol

• TCF6
• TCF6L2
• TCF6
• MTTF1
• MTTFA
• TCF6L1
• TCF6L2
• TCF6L3
• MTDPS15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
molecular function	0.93
histone modification site profile	0.89
transcription factor perturbation	0.84
transcription factor binding site profile	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 904.01   (req: < 5)

Gene RIFs: 154   (req: <= 3)

Antibodies: 495   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 904.01   (req: >= 5)

Gene RIFs: 154   (req: > 3)

Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0