Protein Summary
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
- ENST00000402696
- ENSP00000385834
- ENSG00000091513
- TFQTL1
- PRO1557
- PRO2086
- HEL-S-71p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.99 | ||
chemical | 0.93 | ||
interacting protein | 0.93 | ||
disease | 0.91 | ||
gene perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.59 (req: < 5)
Gene RIFs: 216 (req: <= 3)
Antibodies: 1536 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.59 (req: >= 5)
Gene RIFs: 216 (req: > 3)
Antibodies: 1536 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (314)
GDPD1
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999568668
p_ni: 0.000431332
Data Source: BioPlex
UTP3
Novelty: 0.06371711
p_int: 0.99491222
p_ni: 0.00508778
Score: 0.177
Data Source: BioPlex,STRINGDB
STPG2
Novelty: 0.62741225
p_int: 0.994436437
p_ni: 0.005563563
Score: 0.228
Data Source: BioPlex,STRINGDB
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.992001364
p_ni: 0.007998636
Data Source: BioPlex
MATN3
Novelty: 0.00426202
p_int: 0.977789847
p_ni: 0.022210153
Score: 0.922
Data Source: BioPlex,STRINGDB
MAPK6
Family: Kinase
Novelty: 0.01012514
p_int: 0.975179303
p_ni: 0.024820697
Data Source: BioPlex
SYT17
Novelty: 0.03921503
p_int: 0.953220076
p_ni: 0.046779924
Score: 0.219
Data Source: BioPlex,STRINGDB
ALDH2
Family: Enzyme
Novelty: 0.00077122
p_int: 0.948693937
p_ni: 0.051306063
Score: 0.231
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (24)
Reactome (15)
KEGG (3)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Hemostasis | ||||
Reactome | Iron uptake and transport | ||||
Reactome | Membrane Trafficking | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Hemostasis | ||||
Iron uptake and transport | ||||
Membrane Trafficking | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (5)
Components (22)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
iron biomarker measurement | 7 | 6 | 7 | 13.5 | 99.5 | ||||
transferrin measurement | 2 | 3 | 4 | 98.2 | |||||
transferrin saturation measurement | 3 | 4 | 5 | 98 | |||||
mean corpuscular hemoglobin concentration | 5 | 5 | 6 | 97.9 | |||||
alcohol drinking | 1 | 3 | 3 | 93.7 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
iron biomarker measurement | 7 | 13.5 | 99.5 | ||||
transferrin measurement | 4 | 98.2 | |||||
transferrin saturation measurement | 5 | 98 | |||||
mean corpuscular hemoglobin concentration | 6 | 97.9 | |||||
alcohol drinking | 3 | 93.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transferrin | VGNC:12236 | 460710 | |||||
Macaque | serotransferrin | 106992286 | ||||||
Mouse | MGI:5141890 | |||||||
Rat | RGD:3845 | 24825 | ||||||
Cow | transferrin | 280705 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transferrin | |||||
Macaque | serotransferrin | |||||
Mouse | ||||||
Rat | ||||||
Cow | transferrin | |||||
Publication Statistics
PubMed Score 401.59
PubMed score by year
PubTator Score 14014.22
PubTator score by year
Related Publications
Text Mined References (332)
GeneRif Annotations (216)
Items per page:
0 of 0
PMID | Year | Title |
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