Tdark TEX35 Testis-expressed protein 35

Protein Summary

Uniprot Accession IDs

• Q5T0J7
• Q5T0J8
• Q5T0J9
• Q8IYU6
• Q8N7Z1
• Q8NA15
• Q9H0Q7

Gene Name

• TEX35

Ensembl ID

• ENST00000319416
• ENSP00000323795
• ENSG00000240021
• ENST00000367639
• ENSP00000356611
• ENST00000367641
• ENSP00000356613
• ENST00000367643
• ENSP00000356615

Symbol

• C1orf49
• TSC24
• C1orf49

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.59
cell line	0.56
cell type or tissue	0.56
cellular component	0.56
tissue sample	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.57   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.57   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (44)

Explore Interacting Targets

1 – 10 of 44

• See Interactions on String-DB

BORCS7

Tbio

Novelty:  0.14135922

p_int:  0.999999647

p_ni:  3.31e-7

p_wrong:  2.2e-8

Score:  0.202

Data Source:  BioPlex,STRINGDB

BORCS5

Tdark

Novelty:  0.59333419

p_int:  0.999995869

p_ni:  0.000004131

Score:  0.173

Data Source:  BioPlex,STRINGDB

DTNBP1

Tbio

Novelty:  0.00341619

p_int:  0.999929755

p_ni:  0.000070245

Score:  0.159

Data Source:  BioPlex,STRINGDB

BLOC1S1

Tbio

Novelty:  0.02921036

p_int:  0.999898537

p_ni:  0.000101414

p_wrong:  4.9e-8

Score:  0.653

Data Source:  BioPlex,STRINGDB

GOLGA2

Tbio

Novelty:  0.00544771

p_int:  0.99959951

p_ni:  0.00040049

Data Source:  BioPlex

PLCD1

Tchem

Family:  Enzyme

Novelty:  0.00742197

p_int:  0.999484001

p_ni:  0.000515957

p_wrong:  4.2e-8

Data Source:  BioPlex

BLOC1S2

Tbio

Novelty:  0.02346362

p_int:  0.998980243

p_ni:  0.001019363

p_wrong:  3.94e-7

Score:  0.539

Data Source:  BioPlex,STRINGDB

CALHM4

Tdark

Family:  IC

Novelty:  2.79788039

p_int:  0.998742578

p_ni:  0.001257326

p_wrong:  9.6e-8

Score:  0.191

Data Source:  BioPlex,STRINGDB

LYG2

Tbio

Family:  Enzyme

Novelty:  0.12091256

p_int:  0.998093735

p_ni:  0.001906265

Data Source:  BioPlex

DSG4

Tbio

Novelty:  0.01599371

p_int:  0.996492552

p_ni:  0.003507448

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Components (2)

Find Similar Targets

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
microtubule cytoskeleton	Inferred from Direct Assay (IDA)	LIFEdb
nucleus	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	6	3	10		87
serum gamma-glutamyl transferase measurement	EFO_0004532	2	2	2		83
red blood cell distribution width	EFO_0005192	2	2	2		67.3
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		63.1
triglyceride measurement	EFO_0004530	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	10		87
serum gamma-glutamyl transferase measurement	EFO_0004532	2		83
red blood cell distribution width	EFO_0005192	2		67.3
apolipoprotein A 1 measurement	EFO_0004614	1		63.1
triglyceride measurement	EFO_0004530	1		33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
high density lipoprotein cholesterol measurement
red blood cell distribution width
serum gamma-glutamyl transferase measurement
triglyceride measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	testis expressed 35	VGNC:10936	457548
Macaque	testis expressed 35		717255
Mouse	testis expressed 35	MGI:1920685	73435
Rat	testis expressed 35	RGD:1595460	680164
Dog	testis expressed 35	VGNC:47275	610944

Species	Name	OMA	EggNOG	Inparanoid
Chimp	testis expressed 35
Macaque	testis expressed 35
Mouse	testis expressed 35
Rat	testis expressed 35
Dog	testis expressed 35

Publication Statistics

PubMed Score 1.57

PubMed score by year

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PubTator Score 3.59

PubTator score by year

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Related Publications

Text Mined References (12)

Items per page:

10

0 of 0

PMID	Year	Title