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Tbio
TEX15
Testis-expressed protein 15

Protein Summary
Description
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256246
  • ENSP00000256246
  • ENSG00000133863

Symbol
  • CT42
  • SPGF25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
transcription factor perturbation
0.61
biological process
0.55
cell line
0.55
microRNA
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.02   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.02   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
ATF6B
Tbio
Family:  TF
Novelty:  0.07061573
p_int:  0.995407192
p_ni:  0.000353723
p_wrong:  0.004239085
Score:  0.221
Data Source:  BioPlex,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
p_int:  0.991982236
p_ni:  0.000214932
p_wrong:  0.007802832
Score:  0.309
Data Source:  BioPlex,STRINGDB
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
p_int:  0.917235427
p_ni:  0.002481357
p_wrong:  0.080283216
Score:  0.228
Data Source:  BioPlex,STRINGDB
DMC1
Tbio
Novelty:  0.05445277
Score:  0.939
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.924
Data Source:  STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.919
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.915
Data Source:  STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.914
Data Source:  STRINGDB
UBL4B
Tdark
Novelty:  0.56877836
Score:  0.912
Data Source:  STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic recombination
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic recombination
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
91.5
4
4
3
1
75.7
body mass index
2
2
2
72.1
cognitive function measurement
1
1
1
66.3
waist-hip ratio
2
1
2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
91.5
3
1
75.7
body mass index
2
72.1
cognitive function measurement
1
66.3
waist-hip ratio
2
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
testis expressed 15, meiosis and synapsis associated
VGNC:14599
747054
Macaque
testis expressed 15, meiosis and synapsis associated
695236
Mouse
MGI:1934816
104271
Rat
RGD:1311266
290803
Dog
testis expressed 15, meiosis and synapsis associated
VGNC:47268
100686345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
testis expressed 15, meiosis and synapsis associated
Macaque
testis expressed 15, meiosis and synapsis associated
Mouse
Rat
Dog
testis expressed 15, meiosis and synapsis associated
Publication Statistics
PubMed Score 13.02
PubMed score by year
PubTator Score 6.85
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title