Tchem TET2 Methylcytosine dioxygenase TET2

Protein Summary

Description

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q6N021
• B5MDU0
• Q2TB88
• Q3LIB8
• Q96JX5
• Q9HCM6
• Q9NXW0

Gene Name

• TET2

Ensembl ID

• ENST00000265149
• ENSP00000265149
• ENSG00000168769
• ENST00000305737
• ENSP00000306705
• ENST00000380013
• ENSP00000369351
• ENST00000540549
• ENSP00000442788

Symbol

• KIAA1546
• MDS
• KIAA1546

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
biological term	0.85
microRNA	0.83
transcription factor	0.78
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.85   (req: < 5)

Gene RIFs: 383   (req: <= 3)

Antibodies: 416   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.85   (req: >= 5)

Gene RIFs: 383   (req: > 3)

Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0