TET2
Methylcytosine dioxygenase TET2
Protein Summary
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The enc ...more
- ENST00000265149
- ENSP00000265149
- ENSG00000168769
- ENST00000305737
- ENSP00000306705
- ENST00000380013
- ENSP00000369351
- ENST00000540549
- ENSP00000442788
- KIAA1546
- MDS
- KIAA1546
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.88 | ||
biological term | 0.85 | ||
microRNA | 0.83 | ||
transcription factor | 0.78 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.76 (req: < 5)
Gene RIFs: 223 (req: <= 3)
Antibodies: 416 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.76 (req: >= 5)
Gene RIFs: 223 (req: > 3)
Antibodies: 416 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (125)
NONO
Novelty: 0.00501502
p_int: 0.99999647
p_ni: 0.000003454
p_wrong: 7.5e-8
Score: 0.335
Data Source: BioPlex,STRINGDB
NUP62CL
Novelty: 2.93223607
p_int: 0.999975413
p_ni: 0.000004204
p_wrong: 0.000020383
Data Source: BioPlex
SEMG1
Novelty: 0.0161449
p_int: 0.993702609
p_ni: 0.006296927
p_wrong: 4.64e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Epigenetic regulation of gene expression | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | TET1,2,3 and TDG demethylate DNA | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Epigenetic regulation of gene expression | ||||
Gene expression (Transcription) | ||||
TET1,2,3 and TDG demethylate DNA | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (5)
Components (1)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (64)
Items per page:
1 – 5 of 64
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 7 | 21 | 11 | 6.4 | 93.5 | ||||
lymphocyte count | 4 | 3 | 4 | 93.5 | |||||
7 | 3 | 1 | 1.1 | 93.2 | |||||
self reported educational attainment | 5 | 5 | 4 | 6.9 | 93 | ||||
body height | 3 | 3 | 3 | 92.7 | |||||
Items per page:
1 – 5 of 64
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 11 | 6.4 | 93.5 | ||||
lymphocyte count | 4 | 93.5 | |||||
1 | 1.1 | 93.2 | |||||
self reported educational attainment | 4 | 6.9 | 93 | ||||
body height | 3 | 92.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tet methylcytosine dioxygenase 2 | VGNC:730 | 471263 | |||||
Mouse | MGI:2443298 | 214133 | ||||||
Rat | RGD:1311625 | 310859 | ||||||
Dog | tet methylcytosine dioxygenase 2 | VGNC:47261 | 478499 | |||||
Cow | tet methylcytosine dioxygenase 2 | VGNC:35757 | 538481 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tet methylcytosine dioxygenase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tet methylcytosine dioxygenase 2 | |||||
Cow | tet methylcytosine dioxygenase 2 | |||||
Publication Statistics
PubMed Score 862.76
PubMed score by year
PubTator Score 420.60
PubTator score by year
Related Publications
Text Mined References (244)
GeneRif Annotations (223)
Items per page:
0 of 0
PMID | Year | Title |
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