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Tbio
TESPA1
Protein TESPA1

Protein Summary
Description
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316577
  • ENSP00000312679
  • ENSG00000135426
  • ENST00000449076
  • ENSP00000400892
  • ENST00000524622
  • ENSP00000435622
  • ENST00000531122
  • ENSP00000433098
  • ENST00000532804
  • ENSP00000432030

Symbol
  • KIAA0748
  • HSPC257
  • ITPRID3
  • KIAA0748
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
tissue
0.55
cell type or tissue
0.52
biological process
0.51
phenotype
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.53   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.53   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
p_int:  0.999999994
p_ni:  6e-9
Score:  0.764
Data Source:  BioPlex,STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
p_int:  0.999999959
p_ni:  2.4e-8
p_wrong:  1.7e-8
Score:  0.654
Data Source:  BioPlex,STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
p_int:  0.999999906
p_ni:  9.4e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
BOK
Tbio
Novelty:  0.0154001
p_int:  0.999980494
p_ni:  4e-9
p_wrong:  0.000019502
Score:  0.516
Data Source:  BioPlex,STRINGDB
ITPRID2
Tbio
Novelty:  0.07923791
p_int:  0.998339523
p_ni:  0.001660477
Score:  0.315
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.986944338
p_ni:  0.013055662
Data Source:  BioPlex
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.98668077
p_ni:  0.01331923
Score:  0.211
Data Source:  BioPlex,STRINGDB
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.981058585
p_ni:  0.018941408
p_wrong:  7e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.914459227
p_ni:  0.085540773
Data Source:  BioPlex
YWHAB
Tbio
Novelty:  0.00614093
p_int:  0.914379348
p_ni:  0.085620652
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
2
1
0
1.2
65.9
asthma
2
1
0
1.1
43.1
Eczema
1
1
0
1.1
39.7
1
1
0
1.1
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.2
65.9
asthma
0
1.1
43.1
Eczema
0
1.1
39.7
0
1.1
39.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thymocyte expressed, positive selection associated 1
VGNC:5619
451965
Macaque
thymocyte expressed, positive selection associated 1
704597
Mouse
MGI:1914846
67596
Dog
thymocyte expressed, positive selection associated 1
VGNC:47259
486489
Horse
thymocyte expressed, positive selection associated 1
VGNC:24009
100053043
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thymocyte expressed, positive selection associated 1
Macaque
thymocyte expressed, positive selection associated 1
Mouse
Dog
thymocyte expressed, positive selection associated 1
Horse
thymocyte expressed, positive selection associated 1
Publication Statistics
PubMed Score 12.53
PubMed score by year
PubTator Score 5.39
PubTator score by year
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Related Publications
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PMID
Year
Title